Leland Stanford Junior University

Auckland Uniservices Limited

M's Science Corporation

Ruga Corporation

Verastem, Inc.

Connie L Sun

Amato J Giaccia

Michael Patrick Hay

Muriel Bonnet

Denise Chan

Edwin Lai

Olga Razorenova

Po-wai Yuen

Ray Tabibiazar

Hui-Yin Li

Carl Henry Behrens

Xiaoyuan Li

Raymond Tabibiazar

John Irwin

Yixiong Lei

Patrick Sutphin

Sandra Turcotte

An improved synthesis of a class of inhibitor of Focal Adhesion Kinase (FAK) is provided, wherein use of an expensive palladium-based catalyst is reduced and reaction yields and product purities are improved. Two key reactions of coupling of aryl halides with anilines are optimized with the surprising discovery that the palladium-based catalyst can be dispensed with entirely in one of the reactions. The invention also provides the use of the FAK-inhibitory compounds in the treatment of inflammatory and immune disorders and of arthritis.

Synthesis and use of kinase inhibitors

Provided herein are Substituted Benzamides, compositions, and method of their manufacture and use.

Substituted benzamides and their uses

The present invention provides methods for inhibiting growth and proliferation of HIF pathway proficient cells by administering GLUT1 inhibitors of the invention to HIF pathway proficient cells.

Synthetic lethal targeting of glucose transport

Compounds of general formula (Ia): in which R, A, m, X, n, Y and Rhave any of the meanings given in the specification, have affinity for sigma receptors and are useful in the treatment of disorders of the central nervous system.

Piperidine and piperazine derivatives

Compounds of general formula (I) in which R, m, X, n, Y and Rhave any of the meanings given in the specification, have affinity for sigma receptors and are useful in the treatment of disorders of the central nervous system.

Compounds of general formula (I) in which Rand Rhave any of the meanings given in the specification have affinity for sigma receptors and are useful in the treatment of disorders of the central nervous system.

Piperazine derivatives

Growing community of inventors

Palo Alto, CA, United States of America

Connie L Sun