Analytical Bio-Chemistry Laboratories, Inc.

Fayette Environmental Services, Inc.

Congyuan Guo

David L Stalling

Said Saim

Kenneth C Kuo

Kevin P Kelly

Rhys N Thomas

The present invention relates to a series of nanospheres, having diameters of less than about 50 nm, and having probe ion cores surrounded by layers of surfactant and by a polymer shell. The surface of the shell is functionalized with acid compounds, at least one of which includes a spacer between the nanosphere surface and the acid functionality. In some alternative embodiments, the surface is also functionalized with long-chain ester and alcohol groups. The probe ion core improves the sensitivity and reproducibility of immunoassay procedures. The acid compounds on the surface minimize self-agglomeration of the nanospheres and improve the coupling of the nanosphere with antibodies. The ester and alcohol groups enhance the aqueous suspension characteristics and the shelf life of the nanospheres.

Surface-functionalized, probe-containing nanospheres

The present invention relates to buckminsterfullerenes or related condensed carbon molecules covalently bonded to a polymer particle or a siliceous support particle and their use for packing media for column chromatography.

Chemically bound fullerenes to resin and silica supports and their use

A process has been developed to effectively separate and recover essentially pure amounts of both C.sub.60 and C.sub.70 from carbon soot and higher molecular weight fullerenes. This process first extracts the fullerenes from carbon soot and then sequentially separates the C.sub.60 and C.sub.70 molecules using high performance or low pressure adsorption chromatography packed column containing a gel polymer having aromaticity and a pore size ranging from 10 to 500 .ANG.. In this process, a first stage of fractionation of the fullerenes is preferably accomplished by selective supercritical fluid extraction (SFE) of C.sub.60. Unrecovered C.sub.60 and C.sub.70 molecules are then extracted by supercritical fluid extraction at a higher pressure and/or higher temperature.

Growing community of inventors

Columbia, MO, United States of America

Congyuan Guo