Sanofi

Oval Medical Technologies Limited

Morningside Venture Investments Limited

Chrono Therapeutics Inc.

Sagentia Limited

Varian Medical Systems Particle Therapy Gmbh

Congyi Huang

Alexander David Norman

Timothy Charles Frearson

Gary Stacey

Charles Frazer Kilby

Jennifer Darmour

Alan Joel Levy

Zita S Netzel

Kevin W Gelston

Ling-Kang Tong

David Evans Roth

Patrick H Ruane

Ronald A Overbeck

Jenny E Hapgood

Michael Schabbach

Matthew Egerton Young

Charlotte Emma Harvey

Dieter Kadereit

Dominic Charles Reber

Mark Rogers

Jose Alberto De Los Rios

Andrea Heiberger

Claus Geiger

Andrew Robert Potter

The disclosure refers to a device, for example a cartridge, a syringe or an autoinjector, which reduces the possibility of user error and provides an easy and automatic operation during mixing and/or reconstitution. The device is adapted such that activation of the device causes movement one of a first piston and a second piston in second chamber in an axial direction of the device, thereby moving the other one of the first piston and the second piston into the same axial direction of the device, opening a fluid communication path between the second chamber and a first chamber of the device, and expelling a second material from the second chamber into the first chamber via the fluid communication path. The disclosure is further directed to a respective mixing and/or reconstitution method.

Device and mixing and/or reconstitution method

A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.

Drug delivery methods and systems

Systems and methods for mixing and/or reconstituting drugs are presented. A system may include an injection device, a vial, a needle, and a base station. The device has a chamber containing a first material. The vial has a chamber containing a second material. A drive unit of the base station moves the vial and/or the housing of the device relative to each other into an activated position. In the activated position, the needle is fluidly connected with the vial's chamber, and the drive unit is connected to a driver that moves the plunger in the axial direction of the device such that during fluid connection of the needle with the vial's chamber the first material is expelled from the device's chamber into the vial's chamber or the second material is expelled from the vial's chamber into the device's chamber.

Mixing and/or reconstitution system

A mixing and/or reconstitution system reduces the possibility of user error and provides a well mixed and/or reconstituted drug in a short time. The system comprises a device containing a first material within a first chamber, a housing, and a plunger, the plunger comprising a second chamber containing a second material, wherein one of the first and the second material is a fluid, and a movable element with an electric, magnetic, or paramagnetic characteristic, wherein the second chamber is initially closed; and a base unit comprising a recess for accommodation of the device, a control unit, and an electromagnetic unit which is adapted to produce an electromagnetic field penetrating the recess, wherein the control unit can electrically operate the electromagnetic unit such that the element contained in the second chamber moves in a direction of the device determined by the electromagnetic field and fluidly communicates the first and second chambers.

Mixing and/or reconstitution system and respective method

A proton beam therapy system with a cantilever gantry system and a moving floor system. The moving floor system includes a flexible moving floor and a track that is disposed vertically and affixed to an external wall. The track includes a lateral portion providing a linear lateral path for the part of the moving floor and non-lateral portions providing a vertical path for the excess of the floor. The non-lateral portions may be located above or below the lateral portion. During rotation of the cantilever gantry and when the beam nozzle is positioned under the patient table, an opening is maintained in the floor through which the beam nozzle protrudes. The opening follows the changing positions of the beam nozzle and moves in the floor plane in synchronization with the rotation of the gantry.

Moving floor for radiotherapy system with cantilever gantry assembly

The invention provides a delivery mechanism for an autoinjector comprising: a first drive member configured to drive a first component in an axial direction; a second drive member configured to drive a second component in an axial direction; and a release mechanism configured to control a sequence of release of the first drive member and the second drive member, wherein the release mechanism is positioned at least partially within the first or second drive member.

Delivery mechanism for an autoinjector

The invention provides a drive mechanism for an autoinjector, configured to be coupled to a drug containing portion to form a complete autoinjector, the drive mechanism comprising: a housing (); a drive means coupled to the housing, the drive means comprising a resilient member (); a retaining means coupled to the housing, the retaining means () engaging the drive means in a first position to retain the resilient member in a deformed condition, and releasing the drive means in a second position; and a coupling means () for coupling with a drug containing portion (). The drug containing portion retains the drive means in a second deformed condition when the retaining means is in the second position, the drive means storing enough energy in the second deformed condition to drive needle insertion and/or drug delivery.

Drive assembly for an autoinjector and a method of assembling an autoinjector

Autoinjector with removable cap

Growing community of inventors

Cambridge, United Kingdom

Congyi Huang