Albany Molecular Research, Inc.

Bristol-myers Squibb Compnay

Activbiotics, Inc.

Congxiang Zha

Richard Eric Olson

Shuang Liu

Peter Guzzo

Bruce Francis Molino

David Douglas Manning

Matthew L Isherwood

Kassoum Nacro

Wenge Cui

Min Hu

Aruna Sambandam

Kristen N Fleming

Arthur F Michaelis

Hawkins V Maulding

Chalom B Sayada

Kristen N Ryan

Peter R Guzzo

The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R-Rare as defined herein.

Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II):  where the carbon atom designated * is in the R or S configuration, and the substituents X and R-Rare as defined herein.

The invention features a method of delivering a drug to a diseased cell by linking the drug to a rifamycin derivative, compositions that include drug-rifamycin conjugates of the invention, and methods for treating disease using those compositions.

Targeted therapeutics and uses thereof

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Schenectady, NY, United States of America

Congxiang Zha