Shanghai Yao Yuan Biotechnology Co., Ltd.

China University of Geosciences

Cong Xu

Tian Xu

Xiaodong Chen

Tongruei Raymond Li

Danyang Liu

Jieqing Fan

Yanfang Pan

Lei Huang

Junrong Zhang

Wenbo Zheng

Zongxing Zou

Tao Wen

Miao Yu

Huiming Tang

Junwei Ma

Yongquan Zhang

Yuansheng Wang

Dwayne Tannant

Wengping Gong

The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A, A, L, L, L, Z, Z, W, W, R, R, R, R, R, Rand Rare defined herein.

Compositions and methods of modulating the immune response by activating alpha protein kinase 1

The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A, A, L, L, L, Z, Z, W, W, R, R, R, R, R, Rand Rare defined herein. 

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Shanghai, China

Cong Xu