The Chinese University of Hong Kong

The Hong Kong Polytechnic University

Cong Ma

Xiao Yang

Jiqing Ye

Wan Yi Chan

Paul Kay-sheung Chan

Provided herein are oseltamivir analogs useful for the treatment and prevention of viral infections, pharmaceutical compositions comprising the same and methods preparation and use thereof.

N-substituted oseltamivir derivatives with antimicrobial activity

This invention relates to compounds of formula 1, 2 or 3 a pharmaceutically acceptable salt, or solvate thereof, wherein X, Y, R, R, R, R, and Rare as defined herein. The compounds are antimicrobial agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds and to methods of treating bacterial and protozoal infections by administering the compounds of formula 1, 2 or 3.

Growing community of inventors

Hong Kong, China

Cong Ma