The Provost, Fellows, Scholars and Other Members of Board of Trinity College Dublin

Colm McGarvey

Garrett Ryan

A system for performing a minimally invasive percutaneous procedure comprises a medical device comprising a hydrogel delivery needle () with a tip and a hydrogel outlet (), an injectable, shear-thinning, self-healing viscoelastic hydrogel that exhibits a storage modulus (G') of at least 600 Pa, and a tan δ (G″/G′) from 0.1 to 0.6 in dynamic viscoelasticity measured by a rheometer at 1 Hz and 1% strain rate at 25° C. The system may also comprise a coaxial cannula () having a lumen configured for receipt of the hydrogel delivery needle (), wherein the hydrogel delivery needle comprises an adjustable positioning mechanism () configured to limit the advancement depth of the hydrogel delivery needle through the coaxial cannula to a predetermined depth distal to a distal-most end of the coaxial cannula.

System and methods for sealing a channel in tissue

A system for performing a minimally invasive percutaneous procedure comprises a medical device comprising a hydrogel delivery needle () with a tip and a hydrogel outlet (), an injectable, shear-thinning, self-healing viscoelastic hydrogel that exhibits a storage modulus (G') of at least 600 Pa, and a tan &#x3b4; (G&#x2033;/G) from 0.1 to 0.6 in dynamic viscoelasticity measured by a rheometer at 1 Hz and 1% strain rate at 25&#xb0; C. The system may also comprise a coaxial cannula () having a lumen configured for receipt of the hydrogel delivery needle (), wherein the hydrogel delivery needle comprises an adjustable positioning mechanism () configured to limit the advancement depth of the hydrogel delivery needle through the coaxial cannula to a predetermined depth distal to a distal-most end of the coaxial cannula.

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Colm McGarvey