Interventional Autonomics Corporation

Duke University

Colleen Stack

Richard S Stack

Michael Scott Williams

Richard Glenn

Daniel Wayne Fifer

Terrance J Ransbury

Lynn H Elliott

Geoffrey Orth

William E Sanders

Christopher M O'Connor

Kenneth W Lyles

Cathleen S Colon-Emeric

The present invention provides for methods for treating and/or reducing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, functional analogue or a pharmaceutically effective salt thereof.

Methods for treating heart failure using bisphosphonate compositions

A neuromodulation system for treating acute heart failure syndromes includes a first catheter having a parasympathetic therapy element adapted for positioning within a first blood vessel such as a superior vena cava, and a second catheter sympathetic therapy element adapted for positioning with a second, different, blood vessel such as the pulmonary artery. The catheters comprise a system in which one of catheters is slidably disposed over the other of the catheters. The system may further be slidably disposed over a third elongate element such as a Swan-Ganz catheter positionable within a pulmonary artery, such that the Swan-Ganz may be used for monitoring parameters such as blood pressure and cardiac output during neuromodulation therapy. The parasympathetic therapy element is energized to deliver neuromodulation therapy to a parasympathetic nerve fiber such as a vagus nerve, while the sympathetic therapy element is energized to deliver neuromodulation therapy to a sympathetic nerve fiber such as a sympathetic cardiac nerve fiber. For treatment of acute heart failure syndromes, the neuromodulation therapy may be used to lower heart rate and increase cardiac inotropy.

Neuromodulation systems and methods for treating acute heart failure syndromes

An intravascular electrode system includes an expandable anchor and a flexible substrate which carries at least one electrode. The anchor is positioned in a blood vessel and expanded to an expanded position to bias the electrode in contact with the vessel wall. The flexible substrate may be longitudinally withdrawn from its position between the anchor and the vessel wall without removing the anchor from the blood vessel. A second flexible substrate may be longitudinally inserted into position between the anchor and vessel wall as replacement for the first substrate.

Intravascular electrode system and method

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Chapel Hill, NC, United States of America

Colleen Stack