Wisconsin Alumni Research Foundation

Northern Lights Pharmaceuticals, LLC

Colleen E Hayes

Hector Floyd Deluca

Margherita T Cantorna

Faye E Nashold

Hans W Sollinger

Debra A Hullett

Jean Humpal-Winter

The present invention relates to therapeutics for the prevention and treatment of vitamin D responsive diseases in humans, as well as other animals, through the use of biologically active vitamin D compounds in combination with at least one other immunomodulatory compound such as interleukin-10, interleukin-4, or a TNF&#x3b1; inhibitor.

Treating vitamin D responsive diseases

Methods of treating inflammatory bowel disease are described, and in particular the prevention and treatment of inflammatory bowel disease in humans as well as other animals. These methods involve the administration of biologically active vitamin D compounds, and therapeutic compositions thereof, so that the symptoms of Inflammatory Bowel Disease are reduced or relieved.

Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease

A method of moderating transplant rejection in a transplant recipient comprising administering a dose of vitamin D compound effective to prevent transplant rejection is disclosed. Preferably, the recipient's susceptibility to opportunistic infections has not been compromised. Also preferably, the recipient has not suffered bone demineralization.

Use of vitamin D compounds to prevent transplant rejection

A method of treating arthritis symptoms induced by an infectious agent of an arthritis patient comprising administering to an arthritis patient an amount of vitamin D compound effective to reduce symptoms and observing a reduction in symptoms is disclosed.

Treatment of arthritic disease induced by infectious agents

A method of treating the multiple sclerosis symptoms of a multiple sclerosis patient is disclosed comprising administering to a multiple sclerosis patient an amount of a vitamin D compound effective to reduce symptoms and to enable an observation of a reduction in symptoms.

Growing community of inventors

Madison, WI, United States of America

Colleen E Hayes