Pendulum Therapeutics, Inc.

Pacific Biosciences of California, Inc.

Whole Biome Inc.

Colleen Cutcliffe

John S Eid

James H Bullard

Marcus F Schicklberger

Erik Miller

Satwik Kamtekar

Lei Jia

Walter H Lee

Pranav Patel

Keith P Bjornson

Jeremiah Hanes

Fred C Christians

Arek Bibillo

Tomer Altman

Orville G Kolterman

Robin A Emig

Paul McMurdie

Nicholas Justice

Surabhi Tyagi

Jessica Gines

Andrew T Cheng

Christian Sieber

The disclosure provides compositions and methods for therapeutic administration of the compositions to treat comorbidities associated with gut dysbiosis. The disclosure also provides compositions and methods for increasing engraftment of administered microbes. The disclosure also provides methods for stool sample collection.

Methods and compositions for microbial engraftment

Disclosed herein are methods and compositions for treatment of a microbiome associated disorder. Further, disclosed herein are methods and compositions for modulating short chain fatty acid production in a subject.

Methods and compositions for treatment of microbiome associated disorders

The present disclosure provides methods, systems, compositions, and kits to address the need for microbiome-related treatment of health conditions and disease. The present disclosure provides for treatment of metabolic conditions using microbial compositions.

Methods and compositions relating to microbial treatment and diagnosis of disorders

Methods and compositions for treatment of microbiome-associated disorders

Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties include increased resistance to photodamage, and can also include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.

Recombinant polymerases with increased phototolerance

The present disclosure provides methods for profiling a microbiome and therapeutic compositions for treatment. Additionally, the methods, systems, compositions and kits provided herein are directed to assessing or predicting health status in a subject. Some of the embodiments include generating a report.

Methods and systems for microbiome characterization, monitoring and treatment

Growing community of inventors

Menlo Park, CA, United States of America

Colleen Cutcliffe