Visby Medical, Inc.

Click Diagnostics, Inc.

Helen of Troy Limited

Casper Sleep Inc.

Colin Kelly

Victor Briones

Gregory Loney

David Swenson

Adam De La Zerda

Boris Andreyev

Jesus Ching

Keith Edward Moravick

Brian Ciopyk

Helen Huang

Steven Chu

Brook S Kennedy

Ryan Cena

Eric Freitag

Troy H Phipps

Nicholas A Oxley

Jonathan Newman Cedar

Ryan Vernon

Gary K Schoolnik

Jonathan Hong

Valeria Revilla

Adrienne C Lam

Edward Y Lee

Gina Reimann

Boris Kontorovich

Martin Kay

Elliot Sather

John H Cohen

Charles Simon Paradise

Tyler Moore

Shaunak Roy

Shyam Srinivasan

Ara Acle

Shail Shah

Jeff Chapin

Russell Jelinek

Defne Civelekoglu

Jordan Lay

Phoebe Cao

Josef Norgan

Ryan Young

Eric Lewis

Jeff Mekler

Rajinder K Bhatia

Danielle McSheery

Caroline Cockerham

Gary Schoolnik

Carly Kim

Eric Konzelmann

Jennifer Albrecht

Chris Glaister

Edward Biba

Steve Chu

A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.

Devices and methods for molecular diagnostic testing

A method includes coupling a molecular diagnostic test device to a power source. A biological sample is conveyed into a sample preparation module. The device is then actuated by only a single action to cause the device to perform the following functions without further user action. First, the device heats the sample via a heater of the sample preparation module to lyse a portion of the sample. Second, the device conveys the lysed sample to an amplification module and heats the sample within a reaction volume of the amplification module to amplify a nucleic acid thereby producing an output solution containing a target amplicon. The device then reacts, within a detection module, each of (i) the output solution and (ii) a reagent formulated to produce a signal that indicates a presence of the target amplicon within the output solution. A result associated with the signal is then read.

Portable molecular diagnostic device and methods for the detection of target viruses

A temperature-regulating mattress system provides dynamic adjustment of temperature and other parameters throughout a user's sleep cycle to maximize the quality of the user's sleep, Features of the system may include: (a) heating and cooling temperature regulation (with dynamic custom profiles that control humidity and are dual-zone); (b) smart controls (with remotes and apps that learn from users to optimize settings and work with smart home products such as Alexa and interactive lighting systems); (c) comfort (with a mattress that provide the necessary support for its users); and (d) sensors used for temperature and humidity estimation algorithms, control mechanism, and additional inferences from those sensors (pose, enrichment of biometric sensing data, etc.).

Temperature-regulating mattress

Disclosed herein are methods and devices for preparing a sample of nucleic acid molecules from a biological sample. The methods and devices may perform similarly to or better than standard sample preparation methods. The nucleic acid molecules prepared using the methods and devices provided herein may be utilized for downstream applications, including polymerase chain reaction (PCR).

Devices and methods for nucleic acid extraction

A method includes conveying a detection solution containing a target amplicon into a detection module of a molecular diagnostic test device. The detection module includes a detection surface including a series of capture probes to which a first portion of the target amplicon is bound when the detection solution is conveyed. A first reagent formulated to produce a visible signal indicating a presence of the target amplicon is then conveyed into the detection module. The first reagent is bound to a second portion of the target amplicon when the first reagent is conveyed. A second reagent is conveyed into the detection module. The second reagent includes a precipitating substrate formulated to catalyze the production of the visible signal by producing an insoluble colored product when the second reagent is in contact with the first reagent. The method includes viewing the visible signal via a transparent portion of the detection module.

Devices and methods for the detection of molecules using a flow cell

Detection window for molecular diagnostic device

Status indicator for molecular diagnostic device

Growing community of inventors

San Francisco, CA, United States of America

Colin Kelly