Genentech, Inc.

Curis, Inc.

Colin H Mackinnon

Stephen Colin Price

Edward Andrew Boyd

Oivin M Guicherit

Shirley Ann Brunton

John Harry Alexander Stibbard

Judith Helen Boyd, Legal Representative

The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Mediators of hedgehog signaling pathways, compositions and uses related hereto

Mediators of hedgehog signaling pathways, compositions and uses related thereto

The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

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Oxfordshire, United Kingdom

Colin H Mackinnon