Waters Technologies Corporation

Colin Fredette

Senthil Bala

Christopher Seith

Michael R Jackson

Anthony C Jeannotte

Mark Basile

Joshua A Shreve

Joshua A Burnett

Marc E Lemelin

Gurpreet Singh

David A Simpson

Neal Pugh

Rose Solow

Maruth Sok

Carlos Gomez

Dan Sullivan

Described herein are systems and methods used for washing needle assemblies with multiple needles.

Dual delivery needle wash system

Described is a rotary coupling that includes a pair of coupling bodies having parallel (preferably coincident) rotation axes, two cylindrical elements and a preload mechanism. A gap is provided between surfaces on the first and second coupling bodies. The first cylindrical element is disposed on the first coupling body and has a first cylinder axis, and the second cylindrical element is disposed on the second coupling body adjacent to the first cylindrical element and has a second cylinder axis that is perpendicular to the first cylinder axis. The preload mechanism imparts a force to each of the first and second coupling bodies and thereby preloads the first and second cylindrical elements against each other at a point of contact. One example of the preload mechanism includes a pair of magnets disposed opposite each other across the gap and another example of the preload mechanism includes an air bearing.

Rotary coupling with magnetic preload

The invention provides differential refractive index detectors and methods for the use of differential refractive index detectors. In an exemplary embodiment, a differential refractive index detector includes a flow cell body having a proximal end, a distal end, and a flow axis extending between the proximal and the distal end. The flow cell body includes a first chamber and a second chamber and the fluid conduits coupled to the flow cell body can be tapered to reduce dispersion.

Systems and methods for refractive index detection

The present technology relates to methodologies, systems and apparatus for separating a liquid and a gas from a multi-phase flow stream. In particular, a gas-liquid separator having a curvilinear flow path sized is described. The flow path is designed to create a shift in the axial velocity of the primary flow field through the gas-liquid separator and generate a secondary flow field effect perpendicular to the primary flow field. The curvilinear flow path can minimize additional dispersion and provide improved efficiencies in fraction collection.

Low dispersion gas-liquid separator

The present disclosure relates to methodologies, systems and apparatus for cooling a supersaturated or mixed-phase solution to increase the solubility of gases dissolved therein. In a fluid chromatography system, the mobile phase may include a pressurized mixture including a gas, such as CO, and prior to fraction collection and/or detection a portion of the gas is extracted via a gas/liquid separator. Cooling the substantially liquid phase eluent exiting the gas/liquid separator increases the solubility of any remnant gas still dissolved within the eluent. The increased solubility of the remnant gas prevents out gassing, provides more consistent flow of the eluent through the system, and results in more efficient collection and analysis of a desired sample.

Cooling liquid eluent of a carbon dioxide chromatography system after gas-liquid separation

Methods, systems and apparatus are provided for degassing a supersaturated solution. An example degasser is described having a continuous body of gas-permeable tubing to remove an amount of a gas from the supersaturated solution below the gas's saturation point in the supersaturated solution. The degasser can be connected to at least one of a fraction collector or a detector. The example degasser is sized and/or positioned to cause a change in pressure (&#x394;P) across the degasser to drive removal of a dissolved gas from a supersaturated solution passing through the degasser. As a result of the reduction of gas, efficiencies in system flow and fraction collection are achieved.

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Ashland, MA, United States of America

Colin Fredette