Irm LLC

Bell Helicopter Textron Inc.

Colin Fletcher

Michael P Cooke

Ben Wen

Tim Wiltshire

Lisa Tarantino

Karsten Sauer

This invention provides novel methods and compositions for modulating T cell differentiation and T cell responses. The modulators are identified by screening test compounds for ability to modulate an inositol 1,4,5-trisphosphate 3-kinase (IP3K). The IP3K modulators can be further examined for their activity in modulating development of progenitor T cells (e.g., CD4/CD8double positive T cells) into mature CD4or CD8single positive T cells. Pharmaceutical compositions comprising these T cell modulators can be administered to a subject to modulate T cell immune responses, to suppress inflammations, and to treat disease conditions such as autoimmune diseases, graft rejection or allergies.

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Del Mar, CA, United States of America

Colin Fletcher