The Invention Science Fund I LLC

Gearbox LLC

Washington University

Elwha LLC

Colin Derdeyn

Eric Leuthardt

Lowell L Wood, Jr

Roderick A Hyde

Nathan P Myhrvold

Muriel Y Ishikawa

Victoria Y H Wood

Gregory Zipfel

Ralph G Dacey, Jr

Joshua L Dowling

Jordin T Kare

Gregory J Della Rocca

Michael A Smith

Eleanor V Goodall

Clarence T Tegreene

Edward Stuart Boyden

Guy M Genin

Philip V Bayly

Chandu Vemuri

Stephen L Malaska

Lihong V Wang

Donald Leo Elbert

Srikanth Singamaneni

Paul Santiago

Todd J Stewart

Brittany Scheid

Albert Kim

Ralph Dacey

Yuni Teh

Alan Zhao

Greg Zipfel

Eric Arias

James Norlin

Katie McCoy

Junwoo Suh

A stent for placement in a blood vessel with a wall having an aneurysm including an endovascular graft having a first end, a second end, and a tubular body that is expandable and extends from the first end to the second end. The stent also includes a coagulation apparatus attached to the tubular body between the first and second ends. The coagulation apparatus has a frame and a coagulant attached to the frame. When the stent is deployed within the blood vessel, the tubular body extends across the aneurysm and expands at the first and second ends to seal against the wall of the blood vessel such that blood is channeled across the aneurysm through the tubular body such that a pocket of blood is defined external to the tubular body. The frame expands into the pocket to orient the coagulant therein and promote coagulation of blood within the pocket.

Device and method of inhibiting endoleaks

A breakaway connector generally includes a first valve having a first rotating-type fluid control member, and a second valve that is attachable to the first valve and has a second rotating-type fluid control member. Each of the fluid control members has an open position in which fluid is permitted to flow through the respective valve, and a closed position in which fluid is prevented from flowing through the respective valve. Each one of the valves is configured to engage the fluid control member of the other one of the valves to move the fluid control member from the open position to the closed position upon detachment of the valves from one another.

Breakaway connector

Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.

Method and system for modulating neural activity

Methods and related systems for modulating neural activity by cyclically modulating neural activity in peripheral neural structures are disclosed. Neural activity may be modulated cyclically by stimuli delivered via various types of stimulus sources. In an aspect, activity of a sensory nerve is modulated. Neural modulation may be used, for example, to modulate an undesired sensation, such as pain, or an immune or inflammatory response or process. Delivery of stimuli for modulating neural activity may be controlled in part in response to an input from a user input device.

A device and methods of use thereof are disclosed herein for a biodegradable optical fiber and a method of producing a device including a biodegradable optical fiber. A device is disclosed that includes: a biodegradable optical fiber including; a biodegradable optically functional inner fiber including an optically-transmitting cladding in contact with and surrounding an optically-transmitting core, wherein the inner fiber is biodegradable on a first time scale; and an outer layer in contact with and surrounding the optically-transmitting cladding, wherein the outer layer is biodegradable on a controllably-defined delayed time scale, and the controllably-defined delayed time scale is of greater duration than the first time scale.

Biodegradable optical fibers and methods of use thereof

Methods and related systems for modulating neural activity by cyclical blocking of conduction in peripheral neural structures are disclosed. Neural activity may blocked cyclically by blocking stimuli delivered via various types of blocking stimulus sources. In an aspect, a conduction block is produced in a sensory nerve. Neural modulation may be used, for example, to modulate an undesired sensation, such as pain, or an immune or inflammatory response or process. Delivery of blocking stimuli may be controlled in part in response to an input from a user input device.

Method and system for blocking nerve conduction

Methods and related systems for modulating neural activity by cyclical blocking of conduction in peripheral neural structures with electrical blocking stimuli are disclosed. In an aspect, neural activity is blocked cyclically with an electrical blocking stimulus source implanted adjacent a nerve. In an aspect, a conduction block is produced in a sensory nerve. Neural modulation may be used, for example, to modulate an immune or inflammatory response or process.

Methods and related systems for modulating neural activity by cyclical blocking of conduction in peripheral neural structures with ultrasound are disclosed. In an aspect, neural activity is blocked cyclically with an ultrasonic blocking stimulus source positioned adjacent a skin surface in a vicinity of a nerve. In an aspect, a conduction block is produced in a sensory nerve. Neural modulation may be used, for example, to modulate an immune or inflammatory response or process.

Method and system for ultrasonic neural modulation in a limb

Methods and related systems for modulating neural activity by cyclically blocking conduction in peripheral neural structures are disclosed. In an aspect, neural activity is blocked cyclically with a blocking stimulus source positioned adjacent a skin surface in a vicinity of a nerve. Neural modulation may be used, for example, to modulate an immune or inflammatory response or process.

Method and system for modulating neural activity in a limb

Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Implantable systems for delivery of chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.

Implant system for chemical modulation of neural activity

Method and system for reversible chemical modulation of neural activity

Methods, apparatuses, computer program products, devices and systems are described that include accepting one or more blood vessel sleeve dimensions based on blood vessel data from an individual; and making a rapid-prototyped blood vessel sleeve at least partly based on the one or more blood vessel sleeve dimensions.

Methods and systems for making a blood vessel sleeve

Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Systems for transdermal delivery of chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.

System for transdermal chemical modulation of neural activity

Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with electrical stimuli are disclosed. Methods and systems for reversing effects of blocking stimuli and/or for producing substantially permanent conduction block are also disclosed.

Method for electrical modulation of neural conduction

Methods and related systems for modulating neural activity by repetitively or cyclically blocking conduction in a peripheral neural structure are disclosed. Timing of delivery of blocking stimuli may be based upon overall activity level of the subject or use/activity of a portion of the body of a subject.

Growing community of inventors

St. Louis, MO, United States of America

Colin Derdeyn