Life Technologies Corporation

Biotrove, Inc.

Other

Colin Brenan

John R Linton

Robert A Hess

Tanya S Kanigan

Karl Yoder

Arrin Katz

Javier Garcia

Can C Ozbal

Kristine Friesen

Namyong Kim

Thomas B Morrison

Jamie Cho

Shailesh Srivastava

Leila Marcia Madrone

Steve Smith

Leila Hasan

Robert Harold Ellis

Robert Ellis

Tom Morrison

Peter Madden

Louis Brais

A method of registering a location of a dispenser array in relation to a microfluidic array is provided. One of the dispenser array and the microfluidic array can be movable in relation to the frame, and the other can be fixed relative to the frame. Their relative positions can be identified by a set of coordinates. Identification of a fiducial marker can occur in a manner permitting the fiducial reference to appear in a first position of a field of view of a first camera when the dispenser array or the microfluidic array is in an alignment position. Quantities related to a vector displacement from the alignment position to a fixed position on the microfluidic array or the dispenser array can be identified. Quantities determined can be used to guide positioning of the dispenser array relative to the microfluidic array.

Methods and systems for aligning dispensing arrays with microfluidic sample arrays

A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nanovolume channel having at least one interior surface in communication with the at least one exterior surface. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. Quantities related to a vector displacement from the alignment position to a fixed position on the one of the dispenser array and the microfluidic array is determined. The quantities thus determined are used to guide positioning of the dispenser array relative to the microfluidic array.

Coating process for microfluidic sample arrays

The invention features methods of making devices, or 'platens', having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.

Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof

A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.

Thermal cycling apparatus and method

Thermal cycling assay apparatus and method

Assay apparatus and method using microfluidic arrays

The invention features methods of making devices, or &ldquo;platens&rdquo;, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.

A system and method of automatically assembling voice information and image information into reports or data bases is disclosed. The system uses a microphone connected to a computer for converting spoken words into text and then parses the text to distinguish commands for execution from text information for the report. Commands for image acquisition cause digital images to be inserted within the report or within a database file. Images are associated with text information or with specific locations within the text information. In dependence upon the commands and the associations, a report is automatically generated from pre-recorded information.

Report generation system and method for capturing prose, audio, and

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Marblehead, MA, United States of America

Colin Brenan