Caliper Technologies Corporation

Caliper Life Sciences, Inc.

Sundara Industries, Ltd

Sotax Corporation

Proteinsimple

Other

University of California

Bio-rad Laboratories, Inc.

Original Design Group

Callper Life Sciences, Inc.

Fujifilm Corporation

Wako Pure Chemical Industries, Inc.

Colin B Kennedy

Robert S Dubrow

Luc J Bousse

Robert E Nagle

Morten Juel Jensen

Calvin Y H Chow

Andrea W Chow

Michael Greenstein

Chloe Helen Sundara

Eric Penman Bogner

Anne R Kopf-Sill

Michael A Spaid

Manfred Berndt

Patrick Kaltenbach

Michael J Kennedy

Richard J McReynolds

Peter C Jann

Syed A Husain

John Wallace Parce

Robert Andrew Howard

David G Nilson

David John Roach

Stephan Bianchi

Josh Molho

Alexander V Dukhovny

J Wallace Parce

Leon Kaufman

Allen R Boronkay

David J Chazan

Yoshihiro Seto

Calvin Y Chow

Shinji Satomura

Bruce Anthony Janis

Dale Von Behren

Huan L Phan

Michael M Lacy

Andrew Zee

Jonathan R Harris

Joshua I Molho

Danh C Tran

Stephane Mouradian

Bruce Stephen Levin

Kelly Gardner

Eric Jabart

Yuri Kouchnir

Michael Huston

Daren Walter Hebold

James C Mikkelsen, Jr

Rick Bernal

Evelio Perez

Matthew Latham

Khushroo Gandhi

Daren W Hebold

Robert Nagle

Garrett Unno

Ernest C W Lee

Bruce Stephan Levin

Andrew L Zee

Enrique Bernal

Cheryl Cathey

Jim C Mikkelsen

Youichi Endo

Masayoshi Hayashi

Mitsuo Watanabe

A system for assaying a biological sample for a presence of a target analyte includes an assaying device and a computer controller. The assaying device includes a housing, a receptacle disposed in the housing, and a source of activation energy. The receptacle is configured to accept an electrophoresis cell. The electrophoresis cell has a recess area configured to accept a chip configured to accept the biological sample. The chip includes a polymeric separation medium with activatable functional groups that covalently bond to the target analyte when activated. The source of activation energy is configured to supply activation energy to activate the activatable functional groups. The computer controller is operably coupled to the source of activation energy and is configured to activate the source of activation energy to direct an application of activation energy to the polymeric separation medium to activate the activatable functional groups.

Systems and methods for electrophoretic separation and analysis of analytes

Embodiments of the invention comprise microfluidic devices, instrumentation interfacing with those devices, processes for fabricating that device, and methods of employing that device to perform PCR amplification. Embodiments of the invention are also compatible with quantitative Polymerase Chain Reaction ('qPCR') processes. Microfluidic devices in accordance with the invention may contain a plurality of parallel processing channels. Fully independent reactions can take place in each of the plurality of parallel processing channels. The availability of independent processing channels allows a microfluidic device in accordance with the invention to be used in a number of ways. For example, separate samples could be processed in each of the independent processing channels. Alternatively, different loci on a single sample could be processed in multiple processing channels.

Method and apparatus for use in temperature controlled processing of microfluidic samples

The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 &#x3bc;l to 1 ml from the dissolution vessels to wells of an external receptacle.

Integrated dissolution processing and sample transfer system

The present invention is an automated microfluidic chip processing apparatus that includes a deck for holding at least one microfluidic chip and capable of being accessed by a liquid handling system, a fluid control system, and a detection system, wherein a chip handling device transports the chip from the deck to the fluid control system and the detection system. The present invention also includes a chip for use with an automated microfluidic chip processing apparatus, and a method for processing a microfluidic chip using such an apparatus.

Automated system for handling microfluidic devices

The invention provides fluidic devices having incorporated electrodes. One device comprises a card and first and second caddy segments. The first caddy segment comprises first and second electrodes. The second caddy segment comprises first and second reservoirs disposed on a first surface of the second segment, a channel disposed on a second surface of the second segment, and first and second vias extending between the first and second surfaces. The first caddy segment is attached to the first surface of the second caddy segment. The card is attached to the second surface of the second caddy segment such that the card provides a closed surface for the device.

Fluidic devices having incorporated electrodes

The invention provides fluidic devices having incorporated electrodes. One device comprises a card and a caddy. The card includes a channel disposed within the card, first and second vias in fluid communication with the channel through an upper surface of the card, and first and second electrodes disposed on the upper surface of the card. The first via and first electrode are positioned adjacent to a first end of the channel, and the second via and second electrode are positioned adjacent to a second end of the channel. The caddy comprises first and second reservoirs. The caddy is attached to the card such that the first reservoir is positioned over the first via and a portion of the first electrode, and the second reservoir is positioned over the second via and a portion of the second electrode. A portion of each of the electrodes is accessible for dry electrical contact.

A priming unit for a microfluidics device contains a pressurization unit and pressure and temperature detectors as part of a feedback loop that controls the pressure applied by the pressurization unit and the time during which the pressure is applied. This control feature is particularly useful in controlling the exposure time of the microchannels to dyes in the priming liquids since certain dyes tend to adhere to the walls of the channels and produce non-uniform results.

Apparatus for priming microfluidics devices with feedback control

An electrode alignment apparatus may be used with a microfluidic device for accurate and repeatable alignment of electrode pins with reservoirs on the microfluidic device. The apparatus includes a base unit and an electrode block assembly that are moveable with respect to each other from an open position to a closed position. The electrode block assembly includes an interface array that is coupled to an interface array platform such that the interface array is moveable with respect to the interface array platform in three dimensions.

Electrode apparatus for use with a microfluidic device

In a system for operation or handling of a laboratory microchip () for chemical processing or analysis, the microchip () is mounted in a first physical unit (). The microchip () is arranged on a mounting plate, such that it is readily accessible from the top and thus the fitting and removal of the microchip is considerably simplified. Furthermore, the first physical unit () comprises an optical device () for contactless detection of the results of the chemical processes conducted on the microchip. The supply systems necessary for the operation of the microchip are arranged in a module unit that has a separable connection with a second physical unit. The proposed modular layout enables ease of interchangeability of the required supply systems and thus, overall, ease of adaptability of the proposed system for various types of microchips.

Apparatus for the operation of a microfluidic device

A container is provided for shipping and storing a pre-wetted and pre-conditioned microfluidic 'sipper' chip. The container contains both dry compartments and wet compartments. A base contains a fluid-filled reservoir configured to house the capillaries. The opening of the reservoir is sealed with an O-ring. The plastic mount of the chip rests on the base in a dry compartment. The upper surface of the chip contains several wells containing fluid. A gasket is provided with plugs configured to be disposed within and seal the wells. Alternatively, the wells are first sealed with a foil film adhered to the well openings with an adhesive and a gasket is disposed between the foil and a cover, which is removably attached to the base. When the cover is closed, the gasket and O-ring seal the wet compartments to prevent leakage and to slow evaporation.

Container providing a controlled hydrated environment

Growing community of inventors

Greenbrae, CA, United States of America

Colin B Kennedy