Societe De Conseils De Recherches Et D'applications Scientifiques

Societe De Conseils De Recherches Et D'applications Scientifiques (s.c.r.a.s.)

Colette Broquet

Pierre Braquet

Serge Auvin

Pierre-Etienne Chabrier De Lassauniere

Pierre Etienne Chabrier De Lassauniere

Benedicte Vandamme

Paola Principe-Nicolas

Cyclo-oxygenase inhibitor and amidine derivatives salts, preparation

Arginine analogues having nitric oxide synthase inhibitor activity

The invention relates to compounds of the general formula AB, which may be a salt or an amide, wherein: A represents a cyclooxygenase inhibitor having an accessible acidic function and B represents the L-form of arginine analogues of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 represent various substituents, process for the preparation of such compounds and pharmaceutical composition thereof.

Dual inhibitors of NO synthase and cyclooxygenase, therapeutical

The invention relates to a N-(2,4- or 2,5-disubstituted tetrahydrofuryl alkyl)-N-(phenylethyl-.beta.-ol)amine derivative, under a racemic or enantiomer form, of general formula I ##STR1## wherein R represent various radicals and n is of from 1 to 10, to a process for the preparation of said derivative, and to pharmaceutical compositions comprising the same.

N-derivatives of (phenylethyl-.beta.-ol) amine, a process for their

The invention relates to compounds of the general formula AB, which may be a salt or an amide, wherein:

Dual inhibitors of no synthase and cyclooxygenase, process for their

The invention relates to 3-(N-methyl-N-alkyl)-amino 2-methoxymethylene propan 1-ol derivatives of the formula ##STR1## wherein R stands for an alkyl chain, A stands for: ##STR2## and Y represents various quaternary ammonia, to a preparation process of said compounds and to therapeutic compositions containing the same.

3-(N-methyl-N-alkyl)-amino 2-methoxymethylene propan 1-ol derivatives, a

The invention relates to glycerol derivatives of general formulae Ia, Ib and Ic ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, A and Y stand for various substituents, to a preparation process of said compounds and to therapeutical compositions containing the same.

Glycerol derivatives, and therapeutical compositions containing them

The invention relates to new selenophen derivatives of the formulae, ##STR1## to a preparation process of said compounds and to therapeutic compositions containing the same.

Selenophen derivatives, a preparation process of the same and

The invention relates to new aminoacylates of glycerol acetal of the general formula I ##STR1## wherein R.sub.1 represents a substituted phenyl group or a group of the formula C.sub.m H.sub.2m+1, m being an integer of from 9 to 25,

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Boulogne, France

Colette Broquet