Nederlandse Organisatie Voor Toegepast-natuurwetenschappelijk Onderzoek

Rijksuniversiteit Groningen

Rijksuniversiteit Te Groningen

Explore Incorporated

Coenraad F Lerk

Arie Cornelis Besemer

Pieter De Haan

Adelbert Jozef Schoonen

Johannes S Van Der Hoeven

Mathias J Schaeken

Composition for controlled release of an active substance and method for

The invention relates to an antimicrobial composition on the basis of a physiologically acceptable varnish dissolved therein an antimicrobial agent, preferably chlorhexidine, in an amount sufficient for elimination of Streptococcus mutans in one treatment. This composition can be applied on the tooth surface and other surfaces, such as the skin or on medical instruments.

Antimicrobial composition with long-term activity

The invention relates to a device for the controlled release of one or more active ingredients to a liquid, particularly a controlled release pharmaceutical tablet obtained by compressing a mixture of two granulates in a weight ratio of 30:70 to 70:30, said granulates having particle sizes of 0.4-2.0 mm. One of the granulates, the restraining phase granulate, comprises one or more active ingredients dispersed in a matrix of an insoluble substance, and the other granulate, the housing phase granulate, comprises a soluble material and a penetration rate limiting material, one material optionally having both functions. In the compressed device, the granulates form two distinct phases, each of which is continuous. The housing phase fills large continuous pores in the restraining phase. A zero-order release rate can be obtained with the devices.

Devices for the controlled release of active substances, as well as

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Peize, Netherlands

Coenraad F Lerk