W. L. Gore & Associates, Inc.

Edwards Lifesciences Corporation

W. L. Gore & Assoc. Inc.

Gore Enterprise Holdings, Inc.

Cody L Hartman

William C Bruchman

Dustin V Dienno

Logan R Hagaman

Paul D Gassler

Peter J Walsh

Roy Manygoats, Jr

Ryan S Titone

David J Arcaro

Dustin C Burkart

Edward H Cully

Thomas G Triebes

Kyle W Colavito

Jeffrey B Duncan

Carey V Campbell

James D Silverman

Bret J Kilgrow

Deenu G Kanjickal

Joseph B Koenig

James J Nickerson

Russell L Jacoby

Joshua C Haarer

Roark N Wolfe

Benjamin A Smith

Charles F White

Eric M Tittelbaugh

Larry J Kovach

David M Warlop

James L Goepfrich

Nathan L Bennett

Michael J Vonesh

Benjamin M Trapp

Mei Li

Paul D Drumheller

Robert L Cleek

Steven J Masters

Bruce M Steinhaus

Nathan L Friedman

Thomas R McDaniel

Brandon A Lurie

Theresa A Holland

Nathan K Mooney

Joshua J Lovekamp

Roy Manygoats

Daniel A Crawford

Michael G Dunham

Jane K Bohn

Stephen M Probert

Joshua A Sprinkle

Bill R Finney

Michael J Shepard

Edwin W Field

Olga Baykova

Jason T Alger

Benjamin D Campbell

Ryan D Smith

Karl Busalacchi

Carl M Conway

Vi T Pham

Kevin J Derryberry

Andrew P Hilton

Sudeep Sastry

John R Daugherty

Joel M Greene

Craig T Nordhausen

Thane L Kranzler

Charles J Center

Nichlas L Helder

James F Davidson

Aaron L Paris

Gregory LoStracco

Frank E Myers

Daniel L Crandall

Gregory Lostracco

Thomas R Mcdaniel

Stephen Probert

Willam C Bruchman

Concepts disclosed relate to multi-frame prosthetic valves including leaflet and anchor frame subcomponents, where the leaflet frame subcomponent does not directly couple with patient anatomy and is separated from the anchor frame subcomponent by a gap/space. An optional connecting sheath may be provided to interconnect the subcomponents and assist with prosthetic valve delivery and deployment. One or more bridging members, or annular groove covers, are provided to bridge and cover gap or space between the anchor frame subcomponent and leaflet frame subcomponent, such as at the inflow and/or outflow ends of the subcomponents. Such bridging/cover features may provide smoother flow profiles, reduce incidence of complications, facilitate perfusion during delivery, assist with device nesting during delivery, assist with relative subcomponent positioning following delivery, or provide any of a variety of additional or alternative functions and advantages.

Valve with multi-part frame and associated resilient bridging features

Described embodiments are directed toward centrally-opening leaflet prosthetic valve devices having a leaflet frame and a non-sewn mechanically coupled leaflet. The described leaflet frames have projections that are configured to couple with apertures located within the leaflet attachment region of a leaflet. Some embodiments are further directed toward pulmonary valved conduits incorporating such leaflet and leaflet frame constructs. Methods of making and using such prosthetic valve devices are also described amongst others.

Prosthetic valved conduits with mechanically coupled leaflets

A stent incorporating flexible, preferably polymeric, connecting elements into the stent wherein these elements connect adjacent, spaced-apart stent elements. Preferably the spaced-apart adjacent stent elements are the result of forming the stent from a helically wound serpentine wire having space provided between adjacent windings. Other stent forms such as multiple, individual spaced-apart ring-shaped or interconnected stent elements may also be used. The connecting elements are typically web-shaped and result from creating slits or apertures in a covering of graft material applied to the stent and then, for example, applying heat to cause the slits or apertures to enlarge. The remaining graft material forms the interconnecting webs between the adjacent stent elements.

Stent having adjacent elements connected by flexible webs

Prosthetic heart valve leaflets of shapes that control bending. Prosthetic heart valves can include a leaflet frame having a generally tubular shape with attached film. The leaflet frame can define a plurality of leaflet windows with the film defining at least one leaflet extending from each of the leaflet windows. Each leaflet attachment zone on the leaflet frame may have substantially the shape of an isosceles trapezoid having two leaflet sides, a leaflet base and a leaflet free edge opposite the leaflet base. The two leaflet sides can diverge from the leaflet base, the leaflet base being substantially flat.

Prosthetic valves, frames and leaflets and methods thereof

An improved medical device reduces the loss of longitudinal length during expansion of a stent-graft from a compressed state to an expanded state. For example, the stent-graft is placed over a cover that provides resistance to expansion of the balloon during inflation, which reduces longitudinal compressing forces exerted on the stent-graft.

Balloon expandable endoprosthesis

Described embodiments are directed toward prosthetic valves and systems and methods of making prosthetic valves. In accordance with an embodiment, a prosthetic valve comprises and leaflet frame, and outer frame and a film. The leaflet frame has a generally tubular shape defining a plurality of leaflet windows. The outer frame has a generally tubular shape. The leaflet frame is coaxially disposed at least partially within the outer frame. The leaflet frame and outer frame is coupled at least in part by a contiguous portion of the film. At least a portion of the contiguous portion of the film is contained between and coupling the leaflet frame and outer frame operable to prevent relative movement and contact therebetween. The film defines a leaflet extending from each of the leaflet windows.

Multi-frame prosthetic heart valve

Described embodiments are directed toward prosthetic valves having leaflets of particular shapes that control bending character. In accordance with an embodiment, a prosthetic valve has a plurality of leaflets. Each leaflet includes a central region and two side regions on opposite sides of the central region. The central region is defined by a shape of an isosceles triangle defined by two central region sides, the leaflet base and the leaflet free edge, wherein the two central region sides converge from the leaflet base. Each of the two side regions has a shape of a triangle and each is defined by one of the central region sides, one of the leaflet sides, and the leaflet free edge.

Geometric control of bending character in prosthetic heart valve leaflets

Described embodiments are directed toward centrally-opening leaflet prosthetic valve devices having a leaflet frame coaxially disposed within a body frame, as well as methods of making the valve devices.

Multi-frame prosthetic valve apparatus and methods

An implantable device is disclosed. The device includes a leaflet frame subcomponent and an anchor frame subcomponent that are configured to be delivered in a series configuration and subsequently nested or telescoped in-situ.

Telescoping prosthetic valve with retention element

An implantable device is disclosed. The device includes a two or three-piece frame assembly that is configured to be delivered in a series configuration and subsequently nested or telescoped in-situ.

Telescoping prosthetic valve and delivery system

Described embodiments are directed toward centrally-opening leaflet prosthetic valves having a frame and a leaflet construct. Leaflet frame attachments for prosthetic valves include the leaflet construct being at least partially coupled to a frame outer side by a looped structure.

Leaflet frame attachment for prosthetic valves

Described embodiments are directed toward centrally-opening leaflet prosthetic valve devices having synthetic leaflets that are configured to promote and encourage tissue ingrowth thereon and/or therein. The leaflets are coupled to a leaflet frame to form a prosthetic valve suitable for use in biological anatomy.

Medical valve and leaflet promoting tissue ingrowth

Described embodiments are directed toward prosthetic valves having a support structure and at least one leaflet. The leaflet comprises means for allowing fluid that is behind the leaflet to pass through to the front of the leaflet when the leaflet is not in the closed position. The prosthetic valve includes a leaflet moveable between an open position that permits antegrade flow through the prosthetic valve and a closed position that prevents regurgitant flow through the prosthetic valve, the leaflet having an aperture or gap, or a separation of portions of the leaflet to allow a flow or exchange of fluid between a front and back of the leaflet, when the leaflet is not in the closed position.

Prosthetic valve with improved washout

Described embodiments are directed toward centrally-opening leaflet prosthetic valve devices having a leaflet frame and a mechanically coupled leaflet. The described leaflet frames have projections that are configured to couple with a leaflet attachment region of a leaflet. Some embodiments include a leaflet retention feature that engages the leaflet frame projections and operates to secure the leaflet to the leaflet frame. Methods of making and using such prosthetic valve devices are also described.

Prosthetic valves with mechanically coupled leaflets

Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a prosthetic valve. The prosthetic valve may include a jacket configured to cover at least one of gaps, spaces, or interfaces in a frame or between one or more leaflets attached to the frame.

Jacket for surgical heart valve

Growing community of inventors

Flagstaff, AZ, United States of America

Cody L Hartman