Smithkline Beecham Biologicals S.a.

Clothilde Thiriart

Pierre Hauser

Pierre Voet

Nathalie Marie-Josephe Claude Garcon-Johnson

Claude Artois

Stefan Gabriel Jozef Thoelen

Michael J Clark

Novel vaccine compositions are provided comprising a hepatitis B antigen formulated with aluminium phosphate. The vaccine compositions may additionally contain an inactivated hepatitis A virus, aluminium hydroxide and formol. The combined hepatitis A and B vaccine formulations can, if desired, be administered to human subjects in a 2 dose regimen. Suitable formulations are illustrated.

Composition

A vaccine formulation for the treatment or prophylaxis of hepatitis, especially hepatitis, especially hepatitis B, infections is provided comprising the hepatitis antigen and a suitable carrier such as alum in combination with 3-O-deacylated monophosphoryl lipid. A combination vaccines including the vaccine formulation are also described.

Hepatitis vaccines containing 3-O-deacylated monophoshoryl lipid A

A vaccine formulation for the treatment or prophylaxis of hepatitis, especially hepatitis B, infections is provided comprising the hepatitis antigen and a suitable carrier such as alum in combination with 3-O-deacylated monophosphoryl lipid A. Combination vaccines including the vaccine formulation are also described.

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Brussels, Belgium

Clothilde Thiriart