Chitogenics, Inc.

Kytogenics Pharmaceuticals, Inc.

Her Majesty the Queen in Right of Canada, As Represented by the Minister

American National Red Cross

Nova Chem Limited

The Coalition for Hemophilia B

Clive M Elson

Agis F Kydonieus

Susan Elizabeth Henderson

Timothy D G Lee

Dennis T Curran

Maya Thanou

William N Drohan

Martin James MacPhee

Shirley I Miekka

Manish S Singh

Bryce L Fanning

John R Taylor, Jr

The invention pertains to N-acetylated, N, O-carboxyalkylchitosans and methods for using the chitosans to treat disorders, such as cancer, nervous system disorders, urinary tract disorders, and reproductive tract disorders.

N-acylated chitinous polymers and methods of use thereof

The present invention provides methods and compositions for delivering a therapeutic agent across a membrane that has limited permeability for the therapeutic agent. The method includes delivering the therapeutic agent to the membrane in a composition which includes a sulphated chitinous polymer as a primary carrier.

Methods of drug delivery using sulphated chitinous polymers

The present invention relates to a method of inhibiting cellular and protein attachment to substrates by applying a composition containing an effective amount of adherent N,O-carboxymethylchitosan to a substrate with such that cellular and protein attachment are prevented or greatly reduced.

Adhesive N,O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins

The present invention relates to drug delivery devices for moist tissue, in particular mucosal tissue and tissue in the serous cavities, as well as a method of its use. The devices, which contain NOCC, are adherent to the mucosal tissue, allowing localized drug delivery. The devices are particularly useful in vaginal, buccal and ocular devices.

Adherent N,O-Carboxymethylchitosan drug delivery devices for moist tissue and methods of their use

Adhesive N, O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins

This invention is directed to the preparation and utilization of supplemented chitin hydrogels, such as chitosan hydrogels. Further provided are biomaterials comprising same. The particular supplement delivered by the chitin hydrogel is selected as a function of its intended use. In one embodiment, this invention provides a composition of matter, comprising a chitin hydrogel or chitin-derived hydrogel, wherein the hydrogel does not inhibit full-thickness skin wound healing.

Chitin hydrogels, methods of their production and use

Covalent compositions of N,O-carboxymethyl chitosan (NOCC) are disclosed. NOCC can be intra- or intermolecularly linked, either through a direct bond or through a bridging moiety. Also disclosed are methods for preparing and using the covalent NOCC compositions. The NOCC compositions are useful in the administration of therapeutically active compounds and for wound management.

Covalently linked N,O-carboxymethylchitosan and uses thereof

The invention relates to a method of treating patients to minimize post-surgical adhesions and a kit useful in the method of the invention. The method is based on the timing that N,O-carboxymethylchitosan (NOCC) has advantageous properties as a wound healing lavage and coating. A NOCC solution is particularly effective as a post-surgical lavage and when used in conjunction with a NOCC gel coating, wound healing rate is unchanged while the number and severity of adhesions in greatly reduced.

N,O-carbonxymethylchitosan for prevention of surgical adhesions

The present invention features a method and composition for attracting a target insect to a selected location. The invention is based on the discovery that negatively charged chitosan polymers, e.g., NOCC, have advantageous properties for use in a semiochemical delivery system for releasing a volatile semiochemical at a substantially sustained rate over an extended period of time to attract a target insect to a selected location. The present invention may be used for monitoring a target insect by capturing the insect. Alternatively, the present invention may be used for the management of a target insect by disrupting mating patterns of such insects.

Negatively charged chitosan derivative semiochemical delivery system

New derivatives of carboxymethyl chitosan are disclosed, which are designated as N,O-Carboxymethylchitosonium carboxylates. The derivatives are ammonium salts made by acidifying a substantially neutral suspension of solid N,O-carboxymethyl chitosan in a diluent with an aqueous solution of the carboxylic acid. The carboxylic acid substitutes on the primary amine sites of the N,O-carboxymethyl chitosan.

N-O-carboxymethylchitosonium carboxylate salts

A method for reducing cavitation around underwater acoustic projectors is described. The projector is cleaned with a surfactant and then encapsulated with an aqueous gel containing a polysaccharide polymer such as a chitosan derivative, a hydrophilic stabilizer and a biocide.

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Halifax, Canada

Clive M Elson