Biotech Australia Pty Ltd

University of Wollongong

Pai-2 Pty Limited

Medical Scitec Australia Pty Ltd.

Biotechnology Australia Pty, Ltd

Clive Leighton Bunn

Phillip John Sharp

Barry John Allen

Marie Ranson

Michael A Richardson

Yin Xiao

Peter L Whitfeld

Peter M Bartold

John Lewis Andrews

A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises PAI-2 or a functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2 is bound, linked, or otherwise associated with a toxin or label.

PAI-2 conjugates for the treatment and imaging of cancer

The existence and the extent of periodontal disease can be diagnosed by measuring plasminogen activator inhibitor 2 (PAI-2) and/or tissue plasminogen activator (t-PA) levels in gingival crevicular fluid (GCF). Levels of PAI-2 and t-PA in GCF rise sharply in the context of periodontal disease, and they also correlate with the severity of disease at different sites in the same patient.

PAI-2 and T-PA as diagnostic markers of periodontal disease

The healing of chronic wounds, such as leg ulcers, is accelerated via topical administration of a serine protease inhibitor, such as PAI-2. Wound healing also is promoted using combinations of protease inhibitors, such as PAI-2 with other serine protease inhibitors and/or with protease inhibitors such inhibitors of metalloproteinases, acid proteases, and thiol proteases, respectively.

Use of protease inhibitors for treating skin wounds

Psoriasis may be treated by topical administration of a urokinase inhibitor, such as PAI-2, or a combination of protease inhibitors, such as PAI-2 with other serine protease inhibitors and/or with protease inhibitors such as inhibitors of metalloproteinases, acid proteases, and thiol proteases.

Protease inhibitors for use in the treatment of psoriasis

Polynucleotide constructs for secreted glycosylated plasminogen

Growing community of inventors

West Ryde, Australia

Clive Leighton Bunn