The State University of New York

Other

Juvent, Inc.

The University of North Carolina at Chapel Hill

Exogen, Inc.

American Medical Innovations, LLC

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Marodyne Medical, LLC

Clinton T Rubin

Kenneth J McLeod

Roger J Talish

Janet Rubin

Wei Lin

Yixian Qin

Robert Huang

The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.

Compositions and methods for enhancing the biological response to chemical agents and physical stimuli

A vibration deviceincludes top plate assemblydefining cavitytherein that is configured and dimensioned to receive actuator platesuch that the actuator plateis in direct contact with the top plate assembly. The actuator platetransmits thereby a vibration signal represented by an oscillating vibratory force to the top plate assemblyto operate the oscillating vibration device. Vibration devicefurther includes base plate assemblyfor the vibration device. The top plate assemblyis configured and dimensioned to be mounted on the base plate assembly. The base plate assemblyincludes actuator mounting assemblythat is configured to receive actuatorgenerating a vibration signal represented by an oscillating vibratory force. A method of operating the oscillating vibration deviceincludes transmitting a vibration signal represented by an oscillating vibratory force to foot plate assembly

Low intensity vibration device delivering mechanical signals to biological systems

Systems and methods are disclosed for providing therapeutic treatment using vibrational stimulation, ultrasound stimulation and electro-stimulation. The combined therapeutic treatment allows for more flexible and effective treatment of bone-loss related and other ailments and conditions by providing one or a combination of vibrational, ultrasound and/or electro-stimulation to a patient.

System and method for providing therapeutic treatment using a combination of ultrasound, electro-stimulation and vibrational stimulation

A system and method are disclosed for providing therapeutic treatment using a combination of ultrasound and vibrational stimulation. The system includes a first therapeutic treatment system or Dynamic Motion Therapy system having a vibrational assembly having a non-rigidly supported platform for generating resonant vibrations. The system further includes a second therapeutic treatment system configured to operate either alone or in conjunction with the first therapeutic treatment system. The second therapeutic treatment system includes an ultrasound transducer assembly which generates ultrasonic waves. In one embodiment, the ultrasonic waves are modulated by the resonant vibrations. One method includes: a) applying vibrational stimulation to a patient's body; and b) simultaneously or non-simultaneously applying an ultrasonic stimulation to the patient's body during a treatment session.

System and method for providing therapeutic treatment using a combination of ultrasound and vibrational stimulation

The invention comprises a system and method for determining at least one material property of a material sample (such as a bone sample) at at least one point. The system includes a transmitting ultrasonic transducer and a receiving ultrasonic transducer, both transducers being confocal transducers. The transducers are configured to receive the material sample therebetween such that the confocal point of the transducers are located at the at least one point in the material sample. A processor initiates an ultrasonic signal from the transmitting transducers that is transmitted trough the at least one point of the material sample when positioned between the transducers. The ultrasonic signal is received by the receiving transducing and the processor in turn receives a signal reflecting one or more measures of the received ultrasonic signal. The processor determines at least one ultrasonic parameter for the at least one point of the material sample based upon the transmitted and received ultrasonic signals. The processor further determines the at least one material property at the point of the sample based upon the at least one ultrasonic parameter.

Method and apparatus for scanning confocal acoustic diagnostic for bone quality

A therapeutic device, such as an exercise device, includes the principles of osteogenic repair by incorporating a loading mechanism into the exercise device. By doing so, the therapeutic device provides an increased osteogenic effect, thereby enhancing the benefits of the therapy. As an example, a exercise device includes a support surface for supporting all or part of the bodily tissue of an individual using the device. A linear or rotary loading mechanism associated with the frame or a rotational element of the exercise device drives the support surface at a selected load and frequency, thereby inducing mechanical loading of bodily tissue adjacent to the support surface sufficiently to facilitate the growth, development, strengthening, and/or healing of bone tissue. The loading mechanism may be incorporated into any exercise device, including standard exercise devices such as rowing machines, stair climbing machines, elliptical trainers, bicycles, cross-country ski trainers, treadmills, or weight trainers.

Exercise device utilizing loading apparatus

Vibrational loading apparatus for mounting to exercise equipment

A therapeutic device, such as an exercise device, includes the principles of osteogenic repair by incorporating a vibrational loading mechanism into the exercise device. By doing so, the therapeutic device provides an increased osteogenic effect, thereby enhancing the benefits of the therapy. As an example, an exercise device includes a support surface for supporting all or part of the bodily tissue of an individual using the device. A linear or rotary vibrational loading mechanism associated with the frame or a rotational element of the exercise device drives the support surface at a selected load and frequency, thereby inducing mechanical loading of bodily tissue adjacent to the support surface sufficiently to facilitate the growth, development, strengthening, and/or healing of bone tissue. The vibrational loading mechanism may be incorporated into any exercise device, including standard exercise devices such as rowing machines, stair climbing machines, elliptical trainers, bicycles, cross-country ski trainers, treadmills, or weight trainers.

Exercise equipment utilizing mechanical vibrational apparatus

A method is provided for treating postural instability following a determination that a patient is experiencing postural instability. The method includes the steps of (a) providing a vibration table having a non-rigidly supported platform; (b) permitting the patient to rest on the non-rigidly supported platform for a predetermined period of time; and (c) repeating the steps (a) and (b) over a predetermined treatment duration. Step (b) includes the steps of (b1) measuring a vibrational response of the patient's musculoskeletal system using a vibration measurement device; (b2) performing a frequency decomposition of the vibrational response to quantify the vibrational response into specific vibrational spectra; and (b3) analyzing the vibrational spectra to evaluate at least postural stability. Preferably, the predetermined period of time is approximately 10 minutes and the predetermined treatment duration is at least four weeks.

Non-invasive method for treating postural instability

A non-invasive method for evaluating a musculoskeletal system of a patient is provided which includes the steps of: providing a vibration measurement device in proximity to a non-rigidly supported platform; measuring a vibrational response of the patient's musculoskeletal system using the vibration measurement device after the patient rests on the non-rigidly supported platform; performing a frequency decomposition of the vibrational response to quantify the vibrational response into specific vibrational spectra; and analyzing the vibrational spectra to evaluate muscle strength, postural stability and bone density. A non-invasive physiologic vibration quantification system is also provided for evaluating the musculoskeletal system of the patient. The system includes vibration means for externally transferring vibrations to the musculoskeletal system and including a vibration measurement device for measuring a response by the musculoskeletal system in accordance with the vibrations transferred by the vibration means and for forming signals representative of the musculoskeletal system response; and an analyzer coupled to the vibration measurement device for receiving the signals from the vibration measurement device and developing a frequency spectrum associated with the signals. The frequency spectrum provides vibrational quantification of the musculoskeletal system for evaluating at least postural stability.

Non-invasive method and system of quantifying human postural stability

The present disclosure describes a method of determining the onset of osteoporosis by measuring the vibrational response of the musculoskeletal system. Risk of fracture of bones due to osteoporosis is mainly determined by three risk factors: muscle strength, bone mass, and postural stability. Because these three risk factors for fractures are interrelated and dependent on muscle function, they can be determined by quantifying physiologic vibration non-invasively using a low-mass accelerometer placed at an appropriate muscle belly. Muscle vibrations are produced by force fluctuations of unfused motor units during contraction and are expressed by the lateral expansion of muscle fibers. Muscle vibrational characteristics span a broad (0-100 Hz) frequency regime, directly reflecting the force provided by the muscle fibers being utilized and the nature of the dynamic mechanical milieu experienced by the skeleton during postural or locomotory muscle activity. In addition vibrational information below 5 Hz has been shown to correspond to postural instability. Also, a specific frequency component of the muscle vibration spectrum (25-50 Hz) has now been shown to represent the contribution of fast-oxidative fibers which are well correlated to the bone mineral density of humans. Thus, all three of the major risk factors of fracture are measured by a simple measurement of the musculoskeletal vibration spectrum using physiologic vibration quantification.

Non-invasive method of physiologic vibration quantification

A system for therapeutic treatment of bone includes a source of energy for stimulating a bone, a feedback loop for receiving response information from the bone generated by the stimulation and an adjustment device for adjusting the energy source according to predetermined criteria. A method of therapeutically treating bone includes the steps of providing a source of energy for stimulating a bone, feedback means for receiving response information from the bone generated by the stimulation and adjustment means for adjusting the energy source according to predetermined criteria, applying energy to cyclically stimulate the bone, collecting response information from the bone due to the stimulation, comparing the response information to the predetermined criteria and adjusting the energy source to obtain a response in accordance with the predetermined criteria. The system and method ensure, augment and accelerate the bone healing process.

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Port Jefferson, NY, United States of America

Clinton T Rubin