Thomas Jefferson University

Clinton T Baldwin

Darwin J Prockop

Leena M Ala-Kokko

Gerardus C Tromp

Pertti Ritvaniemi

Ian Hopkinson

Sirpa I Kontusaari

Charlene J Williams

S Helena Kuivaniemi

Nilofer Nina Ahmad

Primers and methods for detecting mutations in the procollagen II gene

Methods of determining genetic predisposition for vascular aneurysm in mammals are disclosed. The base sequence of Type III procollagen DNA of the person tested is compared to the sequence of a standard pro.alpha.l(III) sequence. Differences in the base sequence of the test DNA indicate an increased likelihood that the person will develop vascular aneurysm. Family members of the mammal tested can also be tested to determine if they also have a genetic predisposition to vascular aneurysm by testing for the presence of the mutation in the pro.alpha.l(III) gene of the family members.

Methods of detecting a genetic predisposition for vascular aneurysms

Growing community of inventors

Voorhees, NJ, United States of America

Clinton T Baldwin