Mayo Foundation for Medical Education and Research

US Government As Represented by the Secretary of the Army

Clifton R Haider

Barry K Gilbert

Gary Scott Delp

Stephen J Riederer

Christopher L Felton

David R Holmes, Iii

James Allen Rose

Daniel J Schwab

Patrick Joseph Zabinski

Lukas Smital

Norbert G Campeau

Phillip J Rossman

Gregory A Worrell

Robert W Techentin

Michael J Joyner

Mark E Vickberg

Nathan E Harff

William A Carey

Timothy B Curry

Charlotte Sue Van Dorn

Steven R Clendenen

Victor A Convertino

Oliver William Spees

Systems and methods are provided for evaluating physiological signal quality. A physiological signal, based on a series measurements on a subject, may be received. A quality of the physiological signal received may be evaluated, and an analysis of the physiological signal may be based at least in part on the quality evaluation.

System and method for assessing physiological signal quality

In accordance with some embodiments, systems, methods, and media for estimating compensatory reserve and predicting hemodynamic decompensation using physiological data are provided. In some embodiments, a system for estimating compensatory reserve is provided, the system comprising: a processor programmed to: receive a blood pressure waveform of a subject; generate a first sample of the blood pressure waveform with a first duration; provide the sample as input to a trained CNN that was trained using samples of the first duration from blood pressure waveforms recorded from subjects while decreasing the subject's central blood volume, each sample being associated with a compensatory reserve metric; receive, from the trained CNN, a first compensatory reserve metric based on the first sample; and cause information indicative of remaining compensatory reserve to be presented.

Systems, methods and media for estimating compensatory reserve and predicting hemodynamic decompensation using physiological data

This specification discloses a brain electrode device. The brain electrode device includes a set of contact points and a set of sub-circuits. The sub-circuits include sensor ports configured to connect to the contact to the respective ones of the contact points. The device can further include an intelligent multiplexer that aggregates signals from the set of sub-circuits and generates an aggregate signal. The aggregate signal is transmitted to a signal acquisition device.

Scalable multi-resolution electrode array for sensing and stimulating the brain

In accordance with some embodiments of the disclosed subject matter, mechanisms (which can, for example, include systems, methods, and media) for low-power encoding of continuous physiological signals are provided. In some embodiments, a system comprises: a physiological sensor; and a remote monitor comprising: a battery; memory storing a k-ary tree including a root with k branches corresponding to k delta values, k nodes at a first depth below the Leads root node each having k branches corresponding to the k delta values the nodes indexed to indicate the lateral position of the node within the depth; a processor programmed to: receive a first sample value from the sensor; receive a second sample value; calculate a difference between the second first sample values; determine that the delta corresponds to a first delta of the k delta values; encode a sequence of deltas based on a depth and node index.

Systems, methods, and media for low-power encoding of continuous physiological signals in a remote physiological monitor

Spectrophotometer system configured to characterize and/or measure spectrally (wavelength)-dependent properties of material components (such as molecular, viral, and/or bacterial analytes) associated with or of an object prior to the time when optical fingerprints of such material components start to degrade, and associated methods. System can be enhanced by a capability of selecting specific wavelengths of operation for such system to optimize cost-efficiency of the system.

Spectrophotometer system and enhanced optical characterization of biological samples using same

A fall detection system includes a plurality of sensors in which at least one of the sensors is coupled to or disposed near a floor. The fall detection system further includes a central monitoring system in signal communication with the plurality of sensors. The central monitoring system is configured to receive a response signal in response to an activation signal being transmitted from at least one of the plurality of sensors, and determine whether the response signal is indicative of a person being arranged in a prone position on the floor.

Proximity based fall and distress detection systems and methods

A system and method of dynamically localizing a measurement of parameter characterizing tissue sample with waves produced by spectrometric system at multiple wavelengths and detected at a fixed location of the detector of the system. The parameter is calculated based on impulse response of the sample, reference data representing characteristics of material components of the sample, and path lengths through the sample corresponding to different wavelengths. Dynamic localization is effectuated by considering different portions of a curve representing the determined parameter, and provides for the formation of a spatial map of distribution of the parameter across the sample. Additional measurement of impulse response at multiple detectors facilitates determination of change of the measured parameter across the sample as a function of time.

Spectrometric systems and methods for improved focus localization of time- and space-varying measurements

A system and method for detecting vascular contamination by surgical anesthetic using non-invasive IR spectrophotometry. One embodiment is a method for operating an instrument such as an enhanced pulse oximeter to monitor a patient receiving local anesthetic marked with dye that absorbs infrared light. Light is applied to and detected from tissue of the patient. A signal representative of the detected light is processed to derive patient oxygenation information. The detected light is also processed to derive information representative of the presence of the dye-marked anesthetic. The oxygenation information and the information representative of the presence of anesthetic are displayed. The oxygenation monitoring and display and the anesthetic monitoring and display can occur separately or concurrently. Fluorescing dyes and fluorescence detection approaches are used for anesthetic detection in some embodiments. Other embodiments apply a sequence of light pulses and correlate the applied light pulse sequence to the detected signal to identify the presence of the dye-marked anesthetic.

System and method for detecting vascular contamination by surgical anesthetic using non-invasive IR spectrophotometry

Spectrometric systems and mechanical methods for improved focus localization of time and space-varying measurements

A system and optimization algorithm for determining the preferred operational wavelengths of a device configured for measurement of molecular analytes in a sample. Operational wavelengths are determined by solving a system of equations linking empirically defined functions representative of these analytes, spectrally dependent coefficients corresponding to these analytes, path lengths traversed by waves probing the analytes at wavelengths corresponding to the absorption level described by the functions representative of these analytes, and, optionally, a cost-function taking into account at least one of spectral separation between the operational wavelengths, manufacturability of wave source(s) producing wave(s) at operational wavelength(s), and the noise factor associated with the operation of such wave source(s).

Method and apparatus for selecting wavelengths for optical measurements of a property of a molecular analyte

A system and method are provided for producing a magnetic resonance image of a subject with a magnetic resonance imaging (MRI) system. The method includes acquiring k-space image data from a subject arranged in an MRI system by performing a pulse sequence. To perform the pulse sequence the MRI system divides k-space into a plurality of radially-extending sectors extending along a radial direction away from an origin of k-space. The plurality of radially-extending sectors include a width transverse to the radial direction that is defined by a vane angle chosen to be greater than a floating point precision of the trigonometric functions that define the radially-extending sectors. The MRI system acquires imaging data from at least the radially-extending sectors to undersample the periphery of k-space by only sampling k-space within the plurality of radial sectors and reconstructs an image of the subject using the imaging data.

System and method for random cartesian acquisition with projection reconstruction-like sampling

A method for performing magnetic resonance angiography and perfusion imaging using the same pulse sequence is provided. Time-resolved image data is acquired as a contrast agent passes through a subject. This image data is acquired by sampling Cartesian points in k-space that are contained within either a central region of k-space, or one of a plurality of different sets of radial sectors extending outwards from the central region. The image data is combined to form individual image frame data sets that are then reconstructed to produce a time series of image frames. From this time series, MR angiograms and perfusion maps are produced. With the added acquisition of calibration data, T1 relaxation parameters are estimated and quantitative perfusion maps produced.

System and method for combined time-resolved magnetic resonance angiography and perfusion imaging

A monitor of a physiological parameter of subject under test to which the monitor is attached, in operation. The monitor includes a set of accelerometers operating in different ranges of acceleration and a physiological sensor. The physiological sensor may include an ECG circuit producing an output data characterizing the subject as a function of a degree of motion and/or reorientation of the monitor or an oximeter device. The process of monitoring includes a determination of R-wave of the subject.

Growing community of inventors

Rochester, MN, United States of America

Clifton R Haider