Merck Sharp + Dohme Corp.

Laurus Labs Private Limited

Clifton Leigh

David Waller

Lisa Barton

Gregory Gazda

Zachary Minden

Omar Depaolis

Lyndon Marble

Kirshna R Yalamareddy

Sankar Subramanian

Stephen Mccarron

Krishna R Yalamareddy

Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction.

Synthesis of cephalosporin compounds

Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction. Provided herein are methods for the synthesis of cephalosporin compounds of formula (I) employing a palladium-catalyzed alkylation reaction, as well as compositions related to the same. In an aspect, provided herein is a method for preparing a compound of formula (II), or a salt thereof, comprising the step of admixing, e.g., reacting, a compound of formula (III), or a salt thereof, with a nucleophile (Nuc) in the presence of reagents comprising: (a) a palladium source; and (b) a palladium-binding ligand, to form a compound of formula (II), or a salt thereof.

The present invention generally relates to a process for preparation of 9-halo-3-(2-haloacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one of Formula I, which is an intermediate in the preparation of Hepatitis C Virus (HCV) inhibitors.

Process for the preparation of intermediates useful in the preparation of Hepatitis C virus (HCV) inhibitors

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Windham, NH, United States of America

Clifton Leigh