The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

Clifton L Dalgard

Shiv Srivastava

Albert Dobi

Harvey B Pollard

Meera Srivastava

Ahmed Mohamed

Selective azophenol inhibitors of a wild type or an altered ERG protein expression are described, where the inhibitors represent a compound of Formula (I) or Formula (II) wherein X, X, X, X, Xand X, Rthrough Rand Rare as described.

Azophenols as ERG oncogene inhibitors

The invention relates to methods of determining if a subject is at risk of developing post-traumatic stress disorder (PTSD).

Biomarkers for diagnosing post traumatic stress disorder

Alterations to the ERG gene are some of the most prominent genomic changes associated with many cancers including prostate cancer. Such cancer specific alterations result in the overexpression of wild type ERG protein or an altered ERG protein. The present invention provides selective inhibitors of wild type or an altered ERG protein expression. The ERG inhibitors of the invention, therefore, are therapeutic agents for treating ERG positive cancers.

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Chevy Chase, MD, United States of America

Clifton L Dalgard