Monsanto Company

Alza Corporation

Clifton A Baile

James B Pike

Jonathan P Smith

Stephen M Balaban

Lyle Elmore Ziemann

Jonathan Paul Smith

Thomas Richard Kasser

Jeffrey Wilson Day

Thomas Riley Hampton, Ii

Billy D Vineyard

Carol L McLaughlin

Frances C Buonomo

A method and device for implanting large diameter objects subcutaneously or into the peritoneal cavity of bovines employs a beveled, puncturing, but substantially non-incising trocar.

Method and device for implantation of large diameter objects in bovines

Delivery devices which include a beneficial agent and an activating mechanism in separate compartments separated by a moveable partition are designed to deliver the beneficial agent in a pulsatile manner through an orifice. The pulsatile delivery is achieved by a band of resilient material which is placed over the orifice. The resilient material is sufficiently tight to substantially seal the orifice when the pressure within the device is below a threshold level while at the same time being capable of being stretched when the internal pressure exceeds the threshold.

Delivery devices with pulsatile effect

Alleviation of stomach ulcers in swine which are being administered exogenous somatotropin, by administering to the swine a benzimidazole compound selected from heterocyclylalkyl(sulfinyl or thio)benzimidazoles and [benzimidazolyl(sulfinyl or thio)alkyl]anilines.

Alleviating stomach ulcers in swine

Osmotically driven delivery capsules which include a beneficial agent and a water absorptive osmotic engine in separate compartments separated by a movable partition are designed to deliver the beneficial agent in a pulsatile manner through an orifice. The pulsatile delivery is achieved by a series of stops along the inner wall of the capsule which obstruct the movement of the partition but which are overcome in succession as the osmotic pressure rises above a threshold level. The number of stops and their placement longitudinally along the length of the capsule establish the number and frequency of the pulses, and the configuration of the partition controls the pulse intensity.

Osmotically driven delivery devices with pulsatile effect

Growing community of inventors

Chesterfield, MO, United States of America

Clifton A Baile