Complete Genomics, Inc.

Open Text Corporation

Travera, Inc.

Open Text Ulc

Clifford Reid

Radoje Drmanac

Matthew J Callow

Andrew Sparks

Murray K Low

Charles R Anderson

Selim Olcum

Mark L Stevens

Fredrik Dahl

Rob Kimmerling

Neal Rutta

Kenneth R Grant

Matthew Callow

Murray Low

In silico tools are used to determine possibly effective therapies for treating a patient's cancer based on patient, drug, and cancer information. Functional assays can be performed on living cancer cells from the patient to evaluate the possibly effective therapies along with subsequent genomic or other more destructive assays to provide additional information from a single sample. Drug, patient, cancer, and outcome information can be recorded and updated iteratively and analyzed using machine learning to identify correlations between various patient, cancer, and drug characteristics and expected outcomes and drug efficacies.

Identifying cancer therapies

Methods are provided for efficient shotgun sequencing to allow efficient selection and sequencing of nucleic acids of interest contained in a library. The nucleic acids of interest can be defined any time before or after preparation of the library. One example of nucleic acids of interest is missing or low confidence genome sequences resulting from an initial sequencing procedure. Other nucleic acids of interest include subsets of genomic DNA, RNA or cDNAs (exons, genes, gene sets, transciptomes). By designing an efficient (simple to implement, speedy, high specificity, low cost) selection procedure, a more complete sequence is achieved with less effort than by using highly redundant shotgun sequencing in an initial sequencing procedure.

Efficient shotgun sequencing methods

A system for delivery of content over a wide area network, the content being captured by the system over a time period of a live event, the system comprising a first computer connected to a first side of the wide area network, the first computer having a cache for storing at least one data stream and the first computer having access to executable instruction code in an electronically readable medium. The executable instruction code is for at least: (1) identifying a live portion of the at least one data stream containing content captured by the system, the live portion being that portion of the at least one data stream at the first computer containing content captured more recently by the system than the content contained in any other portion of the at least one data stream at the first computer currently available for sending from the first computer to a second computer, the second computer being connected to a second side of the wide area network; (2) identifying a user position portion of the at least one data stream, the user position portion of the at least one data stream being that portion most recently sent from the first computer to the second computer; (3) receiving a first request at the first computer from the second computer; (4) in response to the first request, sending the live portion of the at least one data stream from the first computer to the second computer; (5) receiving a second request at the first computer from the second computer; and (6) in response to the second request, sending a portion of the at least one data stream from the first computer to the second computer containing content captured less recently by the system than content contained in the live portion of the at least one data stream. The first request and the second request may be sent from the second computer to the first computer and responded to by the first computer in alternating fashion during a time period that at least includes the time period of the live event as extended by a latency period of the wide area network.

Line navigation conferencing system

Growing community of inventors

Pacifica, CA, United States of America

Clifford Reid