The General Hospital Corporation

Harvard College

Children's Medical Center Corporation

California Institute of Technology

Dana-farber-cancer Institute Inc.

Beth Israel Deaconess Medical Center, Inc.

Clifford J Woolf

Tarek A Samad

Herbert Y Lin

Jodie L Babitt

Raymond T Chung

Alan Schneyer

David P Roberson

Bruce P Bean

Brian J Wainger

Sandeep Robert Datta

Alexander Bame Wiltschko

Kevin Eggan, Jr

Evangelos Kiskinis

Paul H Patterson

Kevin C Eggan

Michael Costigan

Alban A Latremoliere

Daniel Broom

Jinbo Lee

Thomas E Scammell

Irmgard Tegeder

Justin K Ichida

Alan L Schneyer

Chloe M Alexandre

Kevin Carl Eggan

Esther Yesde Son

Michael T Do

Qiufu Ma

Chih-Li Chen

Robert Griffin

Sooyeon Jo

Alexandra S Latini

Sebastien Talbot

Nick A Andrews

Jodie Babitt

This disclosure is related to methods of objectively detecting and measuring neuropathic pain in a subject.

Biomarkers of neuropathic pain

A device for detecting and recording animal behavior may include at least one corral that defines a contained field, the base surface of the at least one corral being sensitive to the animal's footprint. The device also includes an image capturing device that cooperates with the base surface to capture both a profile of the animal's full footprint and a profile of the animal's toe print when the animal is standing on its toes. In some embodiments, the device is capable of providing a stimulus to the animal and observing the resulting behavior of the animal via the image capturing device.

Devices and methods for analyzing rodent behavior

The invention provides compounds, compositions, methods, and kits for the treatment of pain, itch, and neurogenic inflammation.

Charged ion channel blockers and methods for use

The invention provides compounds, compositions, methods, and kits for the treatment of neurogenic inflammation.

Permanently charged sodium and calcium channel blockers as anti-inflammatory agents

A device for detecting and recording animal behavior is provided. The device includes at least one corral that defines a contained field, the base surface of the at least one corral being sensitive to the animal's footprint. The device also includes an image capturing device that cooperates with the base surface to capture a first video frame in which at least one of a tail, body and head of the animal is illuminated by a light below the animal and a second video frame in which both a profile of a full footprint and a profile of a toe print of the animal when the animal is standing on its toes is illuminated by a light that is totally internally reflected within the base surface. A control system is arranged to control the image capturing device to capture the first and second video frames.

Devices and methods for analyzing animal behavior

The present invention provides a hemojuvelin (HJV) fusion protein (e.g., a human HJV.Fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also provided are methods for treating iron-related disorders which include administration of a HJV fusion protein to a patient in need thereof.

Nucleic acids encoding hemojuvelin fusion proteins and uses thereof

Described herein are methods and assays relating to the inhibition of sepiapterin reductase and measuring said inhibition by measuring the level of sepiapterin. In some embodiments, the methods can further relate to treating a subject with BH4 and/or BH2.

Methods and assays relating to sepiapterin reductase inhibition

The specification provides compositions and methods to treat neurodegenerative diseases.

Methods to treat neurodegenerative diseases

A device for detecting and recording animal behavior is provided. The device includes at least one corral that defines contained field, the base surface of the at least one corral being sensitive to the animal's footprint. The device also includes an image capturing device that cooperates with the base surface to capture both a profile of the animal's full footprint and a profile of the animal's toe print when the animal is standing on its toes. In some embodiments, the device is capable of providing a stimulus to the animal and observing the resulting behavior of the animal via the image capturing device.

The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels.

Methods, compositions, and kits for treating pain and pruritis

This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, andDragon family members are also disclosed.

DRG11-responsive (DRAGON) gene family

The present invention provides methods of transdifferentiation of somatic cells, for example, directly converting a somatic cell of a first cell type, e.g., a fibroblast into a somatic cell of a second cell type, are described herein. In particular, the present invention generally relates to methods for converting a somatic cell, e.g., a fibroblast into a motor neuron, e.g., an induced motor neuron (iMN) with characteristics of a typical motor neuron. The present invention also relates to an isolated population comprising induced motor neurons (iMNs), compositions and their use in the treatment of motor neuron diseases such as ALS and SMA. In particular, the present invention relates to direct conversion of a somatic cell to an induced motor neuron (iMN) having motor neuron characteristics by increasing the protein expression of at least three motor-neuron inducing (MN-inducing) factors selected from Lhx3, Ascl1, Brn2, Myt1l, Isl1, Hb9, Ngn2 or NeuroD1 in a somatic cell, e.g., a fibroblast to convert the fibroblast to an induced motor neuron (iMN) which exhibits at least two characteristics of an endogenous motor neuron.

Conversion of somatic cells into functional spinal motor neurons, and methods and uses thereof

Hemojuvelin fusion proteins and uses thereof

This invention features antibodies that specifically bind to a murine Dragon family protein.

Antibodies that specifically bind to DRG11-responsive (DRAGON) proteins

Growing community of inventors

Newton, MA, United States of America

Clifford J Woolf