Harvard College

Other

Imperial Cancer Research Technology, Ltd.

Massachusetts Institute of Technology

Imperial Cancer Research Technology Institute

Clifford J Tabin

Andrew P McMahon

Philip W Ingham

Robert Allan Weinberg

Scott M Bradley

David A Bumcrot

Valeria Marigo

Elisa Marti-Gorostiza

Olivia E Orozco

Andrea M Vortkamp

Edward M Laufer

The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.

Hedgehog antibodies

Vertebrate embryonic pattern-inducing proteins, and uses related thereto

Vertebrate embryonic pattern-inducing proteins and uses related thereto

Screening assays for agonists and antagonists of the hedgehog signaling pathway

The present application is directed to the discovery that hedgehog proteins, and agents which effect the activities thereof, can be used to control the formation and/or maintenance of cartilage and bone.

Methods and compositions for regulating skeletogenic formation

Experiments designed to define the differences between the 21 oncogene of DNA isolated from human bladder cancer cells and its corresponding proto-oncogene are described herein. Also described is the determination of the difference between the rat neu oncogene and its corresponding proto-oncogene. Also described are nucleic acid probes reactive with regions of the proto-oncogene or oncogene, as are methods for their use in detecting the occurrence of the two types of genes. Antibodies specific for gene products encoded by the neu genes are also described, as are methods for their use.

Oncogenes and methods for their detection

The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.

Nucleic acids encoding hedgehog proteins

Compositions comprising hedgehog proteins

Method of promoting chondrocyte differentiation with hedgehog related polypeptides

The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vetebrate tissue both in vitro and in vivo.

Vertebrate tissue pattern-inducing proteins, and uses related thereto

Vertebrate embryonic pattern-inducing proteins

Screening assays for hedgehog agonists and antagonists

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Cambridge, MA, United States of America

Clifford J Tabin