Amgen Inc.

Clifford Goodman

Ning Chen

Ana Elena Minatti

Jonathan Dante Low

Anthony B Reed

Shon Booker

Victor J Cee

Brian Alan Lanman

Ryan Paul Wurz

Hui-Ling Wang

Jennifer Rebecca Allen

Albert Kudzovi Amegadzie

Aaron C Siegmund

Vu Van Ma

Jian Jeffrey Chen

Patricia Lopez

Thomas T Nguyen

Nobuko Nishimura

Longbin Liu

Qiufen May Xue

Nuria A Tamayo

Alexander J Pickrell

John Gordon Allen

Mary Walton

Christopher Michael Tegley

Michael J Frohn

David John Kopecky

Youngsook Shin

Kevin Chao Yang

Margaret Chu-Moyer

Qingyian Liu

Matthew Paul Bourbeau

Corey Reeves

Alfonso Pozzan

Iain Lingard

Mary Catherine Walton Cabrera

Federica Tonelli

Giulia Lattanzi

Sabrina Tassini

Jian Chen

The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5D”). The compounds have a general Formula 1: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

Heterocyclic compounds as delta-5 desaturase inhibitors and methods of use

Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

KRAS G12C inhibitors and methods of using the same

Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Substituted piperazines as KRAS G12C inhibitors

Inhibitors of KRAS G12C and methods of using the same

Provided herein are methods of using KRAS G12C inhibitors. These methods of using the inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Growing community of inventors

Thousand Oaks, CA, United States of America

Clifford Goodman