Massachusetts Institute of Technology

The General Hospital Corporation

Cliff Richard Wong

Moungi G Bawendi

Rohit Nandkumar Karnik

Alan J Grodzinsky

Ambika Goel Bajpayee

Rakesh K Jain

Dai Fukumura

August Dorn

Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as osteoarthritis and injury such as trauma.

Surface binding of nanoparticle based drug delivery to tissue

Nanoparticles for a selective, two stage delivery to tumors have been developed. The nanoparticles are initially sized so that they preferentially accumulate in the tumor tissue as a result of leakage through the defective vascular in the solid tumors. Once in the tumor tissue, the nanoparticles are cleaved hydrolytically and/or by enzymatic cleavage over time to release smaller nanoparticles carrying therapeutic, prophylactic or diagnostic agents into the necrotic interior of the tumors. This provides a simple, elegant and highly effective means of delivery drug selectively not just to tumors generally, but, more importantly, into the poorly vascularized necrotic interiors which drugs are normally unable to penetrate. The nanoparticles have a number of advantages: less toxicity due to selective accumulation only in the tumors; access into the poorly vascularized necrotic interiors of the tumor; and sustained release over a period of time within the tumor.

Multistage nanoparticle drug delivery system for the treatment of solid tumors

A population of nanowires can be prepared by a method involving electric field catalyzed growth and alteration based on surface charge density.

Electrically controlled catalytic nanowire growth based on surface charge density

Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as osteoarthritis and injury.

Growing community of inventors

Cambridge, MA, United States of America

Cliff Richard Wong