Warner-lambert Company

Other

Cleo Connolly

Annette M Doherty

Ila Sircar

William Chester Patt

Harriet W Hamilton

Mel C Schroeder

Howard D Showalter

James Marino Hamby

Clifton J Blankley

Robert Lee Panek

6-Aryl naphthyridines are inhibitors of protein tyrosine kinase, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating atherosclerosis, restenosis, psoriasis, as well as bacterial infections.

6-aryl naphthyridines for inhibiting protein tyrosine kinase mediated

6-Aryl pyrido�2,3-d!pyrimidines and naphthyridines are inhibitors of protein tyrosine kinase, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating atherosclerosis, restenosis, psoriasis, as well as bacterial infections.

6-Aryl pyrido�2,3-d! pyrimidines and naphthyridines for inhibiting

The invention concerns novel renin-inhibitory compounds which contain an amino-substituted heterocycle at the P.sub.2 position. These are useful for treating renin-associated hypertension, congestive heart failure, glaucoma, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the compounds, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, or hyperaldosteronism.

Amino-substituted heterocycles as renin inhibitors

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Livonia, MI, United States of America

Cleo Connolly