Basf Se Corporation

Clemens Stückler

Bernhard Hauer

Kurt Faber

Rainer Stürmer

Stephan Maurer

Melanie Bonnekessel

Steffen Maurer

A process for the enzymatic reduction of an enoate (1) wherein the C&#x2550;C bond of the enoate (1) is stereoselectively hydrogenated in the presence of an enoate-reductase and an oxidizable co-substrate (2) in a system which is free of NAD(P)H, in which A is a ketone radical (&#x2014;CRO), an aldehyde radical (&#x2014;CHO), a carboxyl radical (&#x2014;COOR), with R&#x2550;H or optionally substituted C-C-alkyl radical, R, Rand Rare independently of one another H, &#x2014;O&#x2014;C-C-alkyl, &#x2014;O&#x2014;W with W=a hydroxyl protecting group, C-C-alkyl, which can be substituted, C-C-alkenyl, carboxyl, or an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or one of R, Rand Ris a &#x2014;OH radical, or Ris linked to Rso as to become part of a 4-8-membered cycle, or Ris linked to R so as to become part of a 4-8-membered cycle, with the proviso that R, Rand Rmay not be identical.

Process for the enzymatic reduction of enoates

The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents.

Process for the reduction of cinnamaldehyde derivative employing enoate reductases

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Graz, Austria

Clemens Stückler