Smithkline Beecham Corporation

Lg Life Sciences, Limited

Clemens Michael Helmut Brechtelsbauer

Paul William Oxley

Trevor John Grinter

Richard Neville Saunders

Youngwoon Kwon

Yeongdae Kim

Dongchul Lee

Stephen Thomas Carpenter

Michael Anthony Harris

François Xavier Ricard

The invention provides a process for the production of a compound of formula (I): wherein Pand P, which may be the same or different, are amino protecting groups, which comprises protection of a compound of formula (II) in solution phase continuous operation mode. This confers advantages over batch mode operation. The process is usually conducted in reaction equipment adapted for use in continuous processing mode, for example comprising one or more static mixers or a plug flow reactor. Preferably, the plug flow reactor comprises a jacketed tubular reactor fitted inside with internal mixing elements which continually split and remix the reaction streams promoting mass and heat transfer, whereby a uniform plug flow profile with turbulent fluid flow is achieved. The invention also provides a process for production of the antibacterial compound gemifloxacin or a pharmaceutically acceptable salt and/or hydrate thereof, comprising converting a compound of formula (I). The invention also provides a process for the production of a compound of formula (VIIIa) 

Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one and/or 4-aminomethylene-pyrrolidin-3-alkoxyimino derivatives and/or gemifloxacin or a salt thereof

This invention relates to a method for preparing 1-oxaspiro&lsqb;2,5&rsqb;-carbonitriles from ketones using spinning disc reactor technology.

Process for epoxidizing substituted cyclohexanones

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Tonbridge, United Kingdom

Clemens Michael Helmut Brechtelsbauer