The United States of America, As Represented by the Secretary, Department of Health and Human Services

Clay Siegall

Ira H Pastan

David J Fitzgerald

Waldemar Debinski

Prior Trevor

Proteins that are impermeable and foreign to the eukaryotic cells can now be delivered across cellular membranes into the cytosol of target cells by making a chimeric protein having specific attributes. A method of making such chimeric proteins is disclosed. As an example, a chimeric protein PE-Bar with dual enzymatic activity has been made. The chimeric proteins can be used for cytotoxic, diagnostic or therapeutic purposes, such as for compensating the deficiency or defect of an enzyme or a protein which may be causative of a disease or an abnormality.

Growing community of inventors

Silver Springs, MD, United States of America

Clay Siegall