The Ohio State University

Battelle Memorial Institute

Institute for Systems Biology

Clay Braden Marsh

Ali R Rezai

Noura Ismail

Melissa Garnet Piper

Kai Hua Wang

David J Galas

Shile Zhang

Richard Evan Gelinas

Melissa G Piper

Kai Wang

The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of disorders by examining samples containing microvesicles and miRs therein.

MicroRNA expression in human peripheral blood microvesicles and uses thereof

One aspect of the present disclosure relates to a method for treating body organ aging in a mammal. One step of the method includes identifying at least one target organ in need of a therapy signal. Next, a therapy delivery device is placed into electrical communication with an autonomic nervous system (ANS) nerve target and/or a central nervous system (CNS) nerve target associated with the at least one target organ. The therapy delivery device is then activated to deliver the therapy signal to the ANS nerve target and/or the CNS nerve target in an amount and for a time sufficient to effect a change in sympathetic and/or parasympathetic activity associated with the at least one target organ.

Apparatus, systems, and methods for treating body organ aging

Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.

Methods, compositions, and devices utilizing MicroRNA to determine physiological conditions

Growing community of inventors

Columbus, OH, United States of America

Clay Braden Marsh