Schering Aktiengesellschaft

Schering Aktiengeselleschaft

Claus-Steffen Stuerzebecher

Helmut Vorbrueggen

Werner Skuballa

Bernd Raduechel

Olaf Loge

Karl-Heinz Thierauch

Walter Elger

Martin Haberey

Bernd Buchmann

Ekkehard Schillinger

Bob Nieuweboer

Ulrich Klar

Helmut Dahl

Michael H Town

Robert C Nickolson

Werner Witt

The invention relates to 9-halogen-(Z) prostane derivatives of formula I

9-halogen-(Z)-prostaglandin derivatives, process for their production and their use as pharmaceutical agents

The invention relates to 9-halogen-(Z) prostane derivatives of formula I ##STR1## in which ##STR2## Z represents the radicals Hal represents a chlorine or fluorine atom,

9-halogen-(Z) prostaglandin derivatives, process for their production

Combination products containing a prostaglandin (PG), prostacyclin (PC) or a prostacyclin analog (PCA) and a thromboxane receptor antagonist (TXAA) are suitable for joint application to thrombotic and thromboembolic syndromes.

Prostacyclins, their analogs or prostaglandins and thromboxane

The invention relates to carbacyclin derivatives with general formula I: ##STR1## in which Y.sub.1 stands for the radical --CH.sub.2 --X--(CH.sub.2).sub.n --R.sub.1 or the radical ##STR2## n, 1 or 3, R.sub.1, the radical ##STR3## the radical ##STR4## R.sub.9 stands for the radical --(CH.sub.2).sub.m --R.sub.6 or the radical --(CH.sub.2).sub.m-o --[Z.sub.1 --(CH.sub.2).sub.m-p ].sub.x --[Z.sub.2 --(CH.sub.2).sub.m-q ].sub.y --R.sub.6,

Carbacyclins, processes for their preparation, and their use as

(5E)-13,14,18,18,19,19-hexadehydro-3-oxa-6a-carbaprostaglandin I.sub.2 derivatives of Formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 are hydrogen or alkyl of 1-5 carbon atoms, and

Novel carbacyclins, processes for their preparation and their use as

The invention also relates to carbacyclin derivatives of general formula I' ##STR1## wherein R.sub.9 is an alkyl group of 1-10 carbon atoms or the group --C.dbd.C--(CH.sub.2).sub.m --R.sub.6 wherein

New carbacycline, process for their production and their use as a drug

Cyclodextrin clathrates of carbacyclin analogs of general Formula I ##STR1## wherein R.sub.1 is hydrogen, alkyl or alkenyl of up to 10 carbon atoms,

Cyclodextrin clathrates of carbacyclin derivatives and their use as

Carbacyclin derivatives of Formula I ##STR1## wherein R.sub.1 is OR.sub.2 wherein R.sub.2 is hydrogen, C.sub.1 -C.sub.10 -alkyl, C.sub.3 -C.sub.10 -cycloalkyl, C.sub.6 -C.sub.10 -aryl, ##STR2## or a heterocyclic residue, or R.sub.1 is R.sub.3 wherein R.sub.3 is C.sub.1 -C.sub.10 -alkyl, C.sub.3 -C.sub.10 -cycloalkyl, C.sub.6 -C.sub.10 -aryl, C.sub.7 -C.sub.14 -aralkyl or a heterocyclic residue,

Novel carbacyclins, processes for their production and their use as

Carbacyclins of Formula I ##STR1## wherein R.sub.1 is an alkyl, cycloalkyl, aryl, aralkyl, or heterocyclic group,

Growing community of inventors

Berlin, Germany

Claus-Steffen Stuerzebecher