Boehringer Ingelheim Kg

Boehringer Ingelheim Gmbh

Roche Diagnostics Operations, Inc.

Dr. Karl Thomae Gmbh

Boehringer Ingelheim Zentrale

Claus S Schneider

Karl-Heinz Weber

Gerhard Walther

Erich Lehr

Dieter Hinzen

Franz J Kuhn

Wolf D Bechtel

Karin Boke-Kuhn

Joachim Mierau

Gunter Schingnitz

Helmut Ensinger

Wolfgang Troger

Karin Boke

Herbert Merz

Wolf-Dietrich Bechtel

Rudolf Bauer

Matthias Grauert

Rudolf Hurnaus

Walter Kobinger

Adolf Langbein

Ludwig Pichler

Johann-Peter Thalhofer

Armin Fugner

Frank Geipel

Gerhart Griss, Deceased

Stephan Glaser

Hellmut Eckstein

Bernhard Rexer

Stephanie Ronning

Rainer Muller

Michael Ratka

Claudia Giessel

Rainer Sobotta

Karl-Heinz Pook

Armin F/u/ Gner

The present invention concerns a method for producing recombinant trypsin from porcine pancreas inwhich is soluble and secreted into the culture medium, whereby expression at pH 3.0-4.0 substantially prevents activation of trypsinogen to &#x3b2;-trypsin and autolysis of &#x3b2;-trypsin by &#x3b1;-trypsin into &#x3b5;-trypsin and from there into inactive peptides.

Method for producing recombinant trypsin

The invention relates to novel 2,5-diaminotetralines of the formula: ##STR1## wherein R1, R2, R3 and R4 are defined herein, processes for preparing them and their use in pharmaceutical compositions. The novel 2,5-diaminotetralines are useful in treating diseases caused by disorders of the dopaminergic systems.

Method of treating disorders of the dopaminergic systems using

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms; R.sub.2 is 2-, 3- or 4-pyridyl, phenyl or mono- or di-substituted phenyl, where the substituents are each individually alkoxy of 1 to 2 carbon atoms, fluorine, chlorine, bromine, trifluoromethyl, alkyl or 1 to 4 carbon atoms, hydroxyl or nitro; and

N-heterocyclic substituted -pyrrolidin-2-ones

1-(benzyl or pyridylmethyl)-4 or 5-aminomethyl-pyrrolidin-2-ones

Novel compounds having the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein. These compounds are useful in the treatment of schizophrenia.

Use of 2,7-diamino-1,2,3,4-tetrahydronaphthalenes as medicaments, new

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 4 carbon atoms;

1-benzyl-4- or 5-pyrrolidinomethyl-pyrrolidin-2-ones and nootropic

Tetrahydrobenzothiazole derivatives of the formula ##STR1## wherein n is 1, 2 or 3 and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are defined substituents, said derivatives (I) being suitable as active compounds for treating parkinsonism or Parkinson's Disease.

Tetrahydrobenzothiazoles, and the preparation and use thereof

The invention relates to the use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants.

Use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants

The invention relates to new substituted pyrrolidinones of general formula ##STR1## wherein R.sub.1 represents a phenyl group which may be mono- or di-substituted by methyl, methoxy, fluorine, chlorine, bromine or trifluoromethyl, or a pyridyl group;

Nortropanyl containing pyrrolidinones, pharmaceutical compositions and

This invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nucleic may each be substituted by 1 or 2 halogen atoms, R.sub.2 represents a hydrogen atom or an alkyl group, R.sub.3 represents a hydrogen atom, an alkyl group a cycloalkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the phenyl nucleus may be substituted by fluorine, chlorine or bromine atoms, R.sub.4 represents a hydrogen atom, an alkyl group, an alkyl or alkenyl group, or R.sub.3 and R.sub.4 together with the nitrogen atom between them represent a pyrrolidino, piperidino, hexamethyleneimino or morpholino group, the enantiomers and the acid addition salts thereof. The compounds of general formula I above in which one of the groups R.sub.1 or R.sub.3 or both groups R.sub.1 and R.sub.3 represent an acyl group are valuable intermediate products for preparing the other compounds of general formula I which have valuable pharmacological properties. The new compounds may be prepared using methods known per se.

Tetrahydro-benzthiazoles, the preparation thereof and their use as

The invention relates to substituted pyrrolidinones of general formula ##STR1## wherein R.sub.1 represents a phenyl group which may be mono- or di-substituted by methyl, methoxy, fluorine, chlorine, bromine or trifluoromethyl, or a pyridyl group;

Substituted pyrrolidinones, pharmaceutical compositions and use

This invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nuclei may each be substituted by 1 or 2 halogen atoms.

Growing community of inventors

Ingelheim, Germany

Claus S Schneider