Eberhard Karls Universitat Tubingen Medizinische F Akultat

Helmholtz-Zentrum FÜr Infektionsforschung Gmbh FÜr Das Helmholtz-Institut FÜr Pharmazeutische Forschung Saarland (Hips)

Helmholtz-zentrum Fur Infektionsforschung Gmbh (de/de)

Claus-Michael Lehr

Michael Kormann

Brigitta Loretz

Lauren Mays Weddle

Emad Malaeksefat

Hagar Ibrahim Labouta

Sarah Gordon

Arianna Castoldi

Sara Menina

Rebecca Geyer

Annika Kochut

Petra Dersch

Lauren Mays

The present invention relates to a nucleotide-modified messenger RNA for the permanent correction of a genetic alteration on a DNA. The invention further relates to a nucleotide-modified messenger RNA in combination with a repair template. It also relates to a pharmaceutical composition. It finally relates to methods for the correction of a genetic alteration on a DNA.

Permanent gene correction by means of nucleotide-modified messenger RNA

The present invention relates to a carrier system, a carrier and a pharmaceutical composition comprising a pathogen entry protein or fragment thereof, which specifically binds to a molecule on the surface of a mammalian target cell of said pathogen and which is covalently linked to the surface of said carrier and at least one hydrophilic antipathogenic agent. It further relates to a method of manufacturing a carrier system and the carrier system or the pharmaceutical composition for the use as a medicament.

Methods and compositions of carrier systems for the purpose of intracellular drug targeting

Growing community of inventors

Saarbrücken-Dudweiler, Germany

Claus-Michael Lehr