Biotronik Vi Patent Ag

Biotronik Ag

Biotronik Mess-und Therapiegeraete Gmbh & Co.

Universitaet Rostock

Cortronik Gmbh

Universitaet Greifswald

Claus Harder

Bjoern Klocke

Matthias Fringes

Ullrich Bayer

Gernot Kolberg

Wolfgang Geistert

Erhard Flach

Heinz Muller

Bodo Gerold

Heinz Mueller

Alexander Borck

Bernd Heublein

Tobias Diener

Klaus-Peter Schmitz

Alexander Rzany

Katrin Sternberg

Niels Grabow

Robert Schmiedl

Heinz Müller

Werner Weitschies

Heyo K Kroemer

Amir Fargahi

Detlef Behrend

Matthias Gratz

Michael Tittelbach

Marc Kuttler

Elisabeta Burean

Gerd Bayer

Ellen Korzuschnik

Roland Rohde

Peter Littwin

Dailbor Bajer

Dalibor Bajer

Eva Heublein

Christoph Heublein

Bernd (deceasecd) Heublein

Björn Klocke

Burean Elisabeta

Nora Heublein

Claus Martini

Gerhard Hennighausen

Stent, as well as a method and device for fabricating the stent, wherein the stent has a tubular lattice structure comprising individual struts and at least one strut of which at least one longitudinal section runs with at least one directional component in the radial circumferential direction of the stent, wherein the surface of the longitudinal section facing the outside of the stent is curved only about the longitudinal axis of the stent. According to the invention, the surface of longitudinal section of the strut, which surface faces the inside of the stent, has such a curvature that the strut cross section is fluidically optimized.

Stent and method and device for fabricating the stent

A device for coating a stent, including a holder for the stent, a spraying unit comprising a spray mandrel and an air nozzle. The spray mandrel, the air nozzle and the holder are configured and disposed relative to each other such that the spray mandrel projects from one side into the stent during coating and the air nozzle projects into the stent from the opposing side. A method for coating a stent employs the device. Stents that can be obtained according to the method.

Device for coating a stent and associated coating method and stent produced according to the method

The invention concerns an endovascular implant comprising a biodegradable material and having a tubular main body which is open at the ends and which is dilatable from an unexpanded condition into an expanded condition. The implant is so designed that when the implant in the expanded condition is subjected to a radially acting compression pressure in the range of between 5 and 30 kPa (0.05-0.3 bar)

Implant of low radial strength

The invention relates to an implant comprising an active-agent-containing coating which covers the implant at least in sections. The coating is composed of at least two subsections; a first subsection contains the at least one active substance, and a second subsection contains an auxiliary agent.

Implant comprising an active-agent-containing coating covering the implant at least in sections

An implant for releasing an active substance into a vessel through which a body medium flows. The implant release an active substance into a vessel through which a body medium flows downstream from the location of the implant. A base of a biodegradable material is a carrier of the active substance to be released. The body medium flows past the implant and the active substance is release. The implant is configured so that the active substance does not contact a vessel wall at the location of implant.

Implant for releasing an active substance into a vessel through which a body medium flows

The invention relates to an implantation device (-) comprising at least one medical implant (-) and at least one implantation aid (-) comprising at least one expansion element (-). It is provided that the expansion element (-) can be inserted into at least one cavity (-) of the implant (-), and the at least one cavity (-) can be expanded using the expansion element (-), and, in the end state, the expansion element (-) is disposed at least partially in the at least one cavity (-), wherein the expansion element (-) is designed as a solid body (-).

Implantation device

A drug-eluting stent, comprising a base body that is made of an implant material, the base body being partially or entirely covered on the abluminal side with an active ingredient-releasing coating that comprises or is made of a polymer and an active ingredient having an antiproliferative effect, characterized in that the stent's luminal surface and the abluminal surface carrying the active ingredient-releasing coating are covered by a biocorrodible protective layer in a form-fitting manner.

Abluminally coated drug-eluting stents having a form-fitting protective layer

A radio-opaque marker for medical implants comprising between 10 and 90 weight percent of a biodegradable base component, between 10 and 90 weight percent of one or more radio-opaque elements selected from the consisting of I, Au, Ta, Y, Nb, Mo, Ru, Rh, Ba, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Hf, Ta, W, Re, Os, Ir and Bi as a marker component and 10 weight percent of residual components, the aforementioned components amounting to 100 weight percent.

Radio-opaque marker for medical implants

An endoprosthesis, in particular an intraluminal endoprosthesis such as a stent, includes a carrier structure, which includes at least one component containing a magnesium alloy of the following composition:

Endoprosthesis comprising a magnesium alloy

An agent depot for mechanical connection to a surface of an endovascular implantable body, comprising one or more polymers, one or more bioactive agents, the agent depot being mechanically connectable to the implantable body by a force fit or an adhesive.

Medication depot for medical implants

A stent comprising a degradable metal stent main body; a partition layer which is applied to the surface of the stent main body so that at least parts of the surface of the luminal side are not covered; and an agent-containing layer which is applied to the surface of the partition layer at least partially on the abluminal side of the stent main body and comprises one or more agents and possibly one or more polymers.

Degradable metal stent having agent-containing coating

The present invention relates to a method for manufacturing an implant, in particular an intraluminal endoprosthesis, having a body containing metallic material, preferably iron. The following manufacturing method is provided for promotion of the anti-inflammatory effect of the implant: (i) providing the body of the implant; (ii) producing an at least partially closed pore structure in a portion of the structure of the implant body close to the surface; and (iii) incorporating NOinto the cavities of the pore structure. Also described is an implant manufactured in this manner.

Implant and method for manufacturing same

An endoprosthesis includes a carrier structure which contains a metallic material. The metallic material contains a magnesium alloy of the following composition: magnesium: &#x3e;90%, yttrium: 3.7%-5.5%, rare earths: 1.5%-4.4% and balance: &#x3c;1%.

Endoprosthesis

An implant for implantation in a human or animal body having a structure comprising a) an implant base body; b) a primer layer which is partially or completely applied to the surface of the implant; c) an active ingredient layer consisting of one, two, three or more active ingredients applied entirely or partially to the surface of the primer layer; and d) a diffusion-controlling layer which is applied partially or entirely to the active ingredient layer, and optionally to the primer layer, wherein diffusion of the active ingredients of the active ingredient layer is controlled. Also disclosed is a manufacturing method for an implant.

Implants with membrane diffusion-controlled release of active ingredient

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Uttenreuth, Germany

Claus Harder