Children's Medical Research Institute

The United States of America, as Represented by the Secretary, Department of Health and Human Services

The Sydney Children's Hospitals Network (Randwick and Westmead) (Incorporating the Royal Alexandra Hospital for Children)

The Sydney Children's Hospital Network (Randwick and Westmead) (Incorporating the Royal Alexandra Hospital for Children

The Sydney Children's Hospitals Network

Claus Hallwirth

Ian Alexander

Robert Michael Kotin

Richard Smith

The present disclosure relates generally to polypeptides derived from marsupial adeno-associated vims (AAV). The disclosure is also related to nucleic acid molecules encoding the polypeptides, and vectors comprising the nucleic acid molecules, and AAV vectors comprising the polypeptides. The disclosure also relates to uses of the nucleic acid molecules, polypeptides and AAV vectors, such as for capsid diversification.

AAV capsid polynucleotides and polypeptides and virions containing the same

Polypeptides are encoded by an adeno-associated virus (AAV)-derived endogenous viral element (mAAV-EVE1) found within the germline of numerous closely-related marsupial species. Nucleic acid molecules encode the polypeptides. Vectors can include the nucleic acid molecules, and recombinant AAV virions can include the polypeptides. A chimeric capsid protein can also include an MAAV-EVE1 polypeptide.

Adeno-associated virus polynucleotides, polypeptides and virions

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Parramatta, Australia

Claus Hallwirth