Ausimont S.p.a.

Solvay Solexis S.p.a.

Ausimont S.r.l.

Montedison S.p.a.

Austimont S.r.l.

Gambro Lundia Ab

Claudio Tonelli

Vito Tortelli

Stefano Turri

Gianangelo Bargigia

Giovanni Simeone

Marinella Levi

Antonio Russo

Rosaldo Picozzi

Gerardo Caporiccio

Ezio Strepparola

Jacques Chevallet

Massimo Zaccarelli

Vincenzo Baraldi

Giuseppe Gianotti

Antonella Di Meo

Giuseppe Marchionni

Dominique Pouchoulin

Piero Gavezotti

Annalisa Delnevo

Francesco Ribolzi

Jacques Duchamp

Aziz Aberkane

Gabriel Meyssonnier

Luciano Flabbi

Ferdinando Danusso

Fabrizio Mutta

Simonetta Antonella Fontana

Tania Trombetta

Massimo Scicchitano

Graziano Giuseppe Vezzulli

Angelo Locaspi

Leno Mascia

Walter Navarrini

Mario Visca

Cyril Meziere

Patrizia Serenella Maccone

Giampiero Basile

Werner Beck

Alberto Re

Reinhold Deppisch

Ezio Musso

Silvana Modena

Francesco Pilati

Helmut Hildwein

Sauro Girolomoni

Ronald E Zielinski

Maurizio Toselli

Francesco Giavarini

Antonio Turturro

Carlo Pogliani

Jean Louis Fressinet

Alberto Nicoletti

Enrico Ferreri

Ercole Gattiglia

Yves Audouard

Ritalba Lamendola

Alexandre Tchistiakov

Bernd Wittner

Jonas Svensson

Bjorn Ericson

The invention pertains to a process for the manufacture cola medical implant, said process comprising: It has been surprisingly found that by using a mixture of perfluoropolyethers having high functionality, it is advantageously possible to manufacture, by moulding thermoplastic elastomers therefrom, medical implants which exhibit improved biocompatibility and which are submitted to reduced chemicals extraction by biological fluids.

Manufacture of medical implants

A process for the manufacture of a polyol (per)fluoropolyether derivative comprising:

Process for the manufacture of polyol perfluoropolyether derivative

A process for the purification of a tetraol PFPE derivative [tetraol (T)] of formula (I): HO&#x2014;CH&#x2014;CH(OH)&#x2014;CH&#x2014;O&#x2014;CH&#x2014;CF&#x2014;O&#x2014;R&#x2014;CF&#x2014;CHO&#x2014;CH&#x2014;CH(OH)&#x2014;CHOH, wherein Rrepresents a fluoropolyoxyalkene chain (chain R), from a mixture (M) of hydroxyl (per)fluoropolyether derivatives, said mixture comprising said tetraol (T) and at least one hydroxyl (per)fluoropolyether [PFPE (OH)] comprising a chain Rterminated with at least one end group of formula: &#x2014;CFCHOH; &#x2014;CFCHO&#x2014;CH(OH)&#x2014;CH&#x2014;O&#x2014;CH&#x2014;CH(OH)&#x2014;CHOH; said process comprising: step 1: reacting the mixture (M) with ketones and/or aldehydes so as to selectively protect couples of hydroxyl groups on vicinal carbon atoms by forming corresponding cyclic ketal/acetal derivatives, so as to yield a protected mixture (P); step 2: reacting residual hydroxyl groups of the mixture (P) with suitable functionalizing agents enabling substantial volatility modification, so as to obtain a functionalized protected mixture (P); step 3: fractional distillation of the mixture (P) so as to isolate the cyclic acetal/ketal derivatives of tetraol (T); and step 4: hydrolyzing the acetal/ketal derivatives of tetraol (T) so as to recover pure tetraol (T).

Process for the purification of polyol PFPE derivative

Aromatic hydrogenated polymers comprising perfluoropolyether (PFPE) chains bonded to the aromatic rings to form sequences randomly distributed in the polymer structure, having the formula (I): (T-CFO&#x2014;Rf&#x2014;CF)-Tin which: n is an integer from 1 to 10; Tis an aromatic group of the backbone of the hydrogenated polymer, or alternatively condensed aromatic groups; Tmay be equal to T, or alternatively a functional group &#x2014;COOH or &#x2014;COF; Rf is a (per)fluoropolyoxyalkylene chain, in which the starting hydrogenated aromatic polymers are obtained by polycondensation, stepwise polyaddition or polyaddition of cyclic monomers in which the ring is formed by at least 3 atoms.

Aromatic hydrogenated polymers containing fluorine

Compounds having the following formula: wherein:

(PER) fluoropolyether compounds

A process for separating bifunctional perfluoropolyethers (PFPEs) having two terminations &#x2014;CHOH from their mixtures with monofunctional PFPEs with one termination &#x2014;CHOH, of general formulaX&#x2014;O&#x2014;Rf&#x2014;Y &#x2003;&#x2003;(I)wherein Rf is a perfluoropolyoxyalkylene chain having a number average molecular weight of 500-10,000; Xand Y are end groups selected from &#x2014;CFXCHOH (wherein X is F or CF), &#x2014;CF, &#x2014;CFCl, &#x2014;CFCFCl, &#x2014;CFCl, &#x2014;CFBr, &#x2014;CFCF, wherein at least one of the two end groups is &#x2014;CFXCHOH, said process comprising the steps of:

[object Object]

Carboxylic acids comprising perfluoropolyether chains, of formula:T&#x2014;CFW&#x2014;O&#x2014;R&#x2014;CFW&#x2014;T&#x2003;&#x2003;(I)wherein T, T, equal to or different from each other, are selected from the group formed of &#x2014;CH&#x2014;B&#x2014;Y&#x2014;(COOH), &#x2014;CH(CF) O&#x2014;Y(COOH), &#x2014;F, &#x2014;CF, &#x2014;CF, &#x2014;(CF)Cl, wherein B=&#x2014;O&#x2014; or &#x2014;S&#x2014;; Y=C&#x2014;Calkylene chain, n=1-4; with the proviso that at least one of the two end groups T, Tbe &#x2014;CH&#x2014;B&#x2014;Y&#x2014;(COOH), &#x2014;CH(CF)O&#x2014;Y(COOH); W, W, equal to or different from each other, are &#x2014;F or &#x2014;CF; Ris a (per)fluoropolyoxyalkylene chain formed of one or more repeating units, statistically distributed along the chain, having a number average molecular weight in the range 500-10,000.

(per) fluoropolyether carboxylic acids and use thereof for the oleo-repellent paper sizing

Hydrofluoroethers of formula:T-CFX'&#x2014;O&#x2014;R&#x2014;CFX-T&#x2032;&#x2003;&#x2003;(II)wherein:

A process for preparing perfluoropolyethers having at least one &#x2014;CHOH or &#x2014;CH(CF)OH end group by reaction of the corresponding pefluoropolyethers having at least one carboxylic &#x2014;COOH or ketonic &#x2014;(CF)C&#x2550;O end group with gaseous hydrogen, between 80&#xb0; C. and 140&#xb0; C., in the presence of hydrogenation catalysts.

Cyclic phosphazene compounds of formula (I):wherein:

Cyclic phosphazene compounds and use thereof as additives of perfluoropolyether oils

Process for the perfluoropolyether preparation having reactive end groups &#x2014;CHNH, &#x2014;CHO, &#x2014;CHOH, by reduction of the corresponding perfluoropolyethers having &#x2014;CN, &#x2014;COCl, &#x2014;CHO end groups by using gaseous hydrogen in the presence of a catalyst constituted by Pd, Rh, or Ru, supported on solid metal fluorides, at a temperature from 20&#xb0; C. to 150&#xb0; C. and under a pressure between 1 and 50 atm.

Process for the preparation of perfluoropolyethers having aldehyde, alcohol, amine end groups by catalytic reduction

A process for the preparation of perfluoropolyethers of formula:T-CFX'&#x2014;O&#x2014;R&#x2014;CFX&#x2014;COF&#x2003;&#x2003;(I)wherein:

Process for the preparation of perfluoropolyethers acyl-fluoride ended by reduction of the corresponding peroxidic perfluoropolyethers

Process for obtaining mixtures of phosphoric mono- and diesters

Process for the preparation of fluoropolyoxyalkylenes having one end group -CH2OH and the other end group containing chlorine

Process for the preparation of perfluoropolyoxyalkylenes with hydroxyl end groups

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Milan, Italy

Claudio Tonelli