Pharmacia & Upjohn S.p.a.

Pharmacia S.p.a.

Claudio Scotti

Anna Luisa Colombo

Charles Richard Hutchinson

Umberto Breme

Sharee L Otten

Augusto Solari Inventi

Silvia Filippini

The ability to convert daunorubicin to doxorubicin can be conferred on a host cell by transformation with a recombinant vector comprising DNA encoding daunorubicin 14-hydroxylase. The host cell can then be used to produce doxorubicin.

Daunorubin 14-hydroxylase

DNA encoding daunorubicin 14-hyroxylase and method for preparing

The ability to improve the conversion of .epsilon.-rhodomycinone to daunorubicin can be conferred on a bacterial host transformed with a recombinant vector comprising a DNA coding for an appropriate protein useful for that conversion. Furthermore, the bacterial host may have a mutation that blocks the function of a gene of daunorubicin metabolism.

Process for preparing daunorubicin

Growing community of inventors

Motta Visconti, Italy

Claudio Scotti