Medi-physics, Inc.

Claudio Marelli

Bastiaan Driehuys

Margaret Hall

Jan Wolber

Sven Mansson

Sven Mansoon

In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarizedXe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue; (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a respiratory, cardiopulmonary disorder or disease such as chronic heart failure, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.

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Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe

In certain embodiments, methods of the present invention obtain NMR spectroscopy signal data that corresponds to the behavior of the polarizedXe at a selected site(s) in selected environments in vivo. The gas exchange signal data can be used to evaluate: (a) the thickness of a barrier, such as a membrane, lining, wall or width of a lumen; (b) the operational condition or function of a membrane, body system or portion thereof; (c) cerebral perfusion; and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a disorder or disease, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat a disorder or disease.

Methods for in vivo evaluation of physiological conditions and/or organ or system function including methods to evaluate cardiopulmonary disorders such as chronic heart failure using polarized 129 Xe

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Amersham, United Kingdom

Claudio Marelli