Zambon S.p.a.

Zambon Group S.p.a.

Blaschim S.p.a.

Montedison S.p.a.

Blasinachim S.p.a.

Montedison Fibre S.p.a.

Zambon Group

Claudio Giordano

Graziano Castaldi

Fulvio Uggeri

Silvia Cavicchioli

Maurizio Paiocchi

Marco Villa

Francesco Minisci

Aldo Belli

Giovanni Villa

Roberto Casagrande

Laura Coppi

Dario Tentorio

Silvio Levi

Mariano Meneghin

Giulio Perdoncin

Giuseppe Barreca

Claudio Fuganti

Francesco Casagrande

Paolo Cavalleri

Piero Piccinelli

Franco Pozzi

Daniele Donati

Stefano Servi

Laura Russo

Valeriano Merli

Mario Ferraris

Angelo Gentile

Giorgio Sagramora

Luca Ghirotto

Placido Bertin

Elena Barsuglia

Carlo Restelli

Process for the preparation of intermediates useful for the synthesis for benzothiazepines

A process for the preparation of 5-(2,4-difluorophenyl)-salicylic acid comprising the reaction of an organometallic derivative with a suitable substituted benzene in the presence of a transition-metal based catalyst is described.

Process for the preparation of 5-(2,4-difluorophenyl)-salicylic acid

Intermediates for transforming (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R)-enantiomers are described. The final compounds are useful intermediates for the synthesis of antibiotics like chloramphenicol, Thiamphenicol and Florfenicol.

Process for the stereochemical inversion of

A process for the direct and regioselective functionalization of phenothiazine which allows one to introduce an SH group in position 2, said process comprising the sulfination or sulfonation of the phenothiazine N-protected with an alkoxycarbonyl, an alkylsulfonyl or an arylsulfonyl group, the reduction of the produce obtained to give the N-protected 2-mercapto-phenothiazine, and the deprotection of the nitrogen atom. The thus-obtained 2-mercapto-phenothiazine is an important intermediate for the preparation of pharmacological active compounds.

Process for the direct and regioselective functionalization in position

A purification method of intermediates for the preparation of Diltiazem which consists of the crystallization of a mixture enantiomerically enriched in (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H) -one is described.

Process for the single crystallization of enatiomeric ratio's

Intermediates for transforming (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R)-enantiomers are described. The final compounds are useful intermediates for the synthesis of antibiotics like Chloramphenicol, Thiamphenicol and Florfenicol.

Intermediates for the stereochemical inversion of

Compounds of formula ##STR1## (wherein Ar, R, R.sub.1 and X have the meaning reported in the description) are useful intermediates for the preparation of a variety of organic compounds, also optically active, like alpha-haloketones, alpha-hydroxyketones or ketals, alpha-arylalkanoic acids.

Intermediates and their use in the synthesis of organic compounds

A process for the preparation of 4-(2,4-difluorophenyl)-phenyl 4-nitro-benzoate, an intermediate for the preparation of 5-(2,4-difluorophenyl)-salicylic acid, which is a drug known with the international non-proprietary name Diflunisal, is described.

Process for the preparation of 4-(2,4-difluorophenyl)-phenyl

Process for the preparation of (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H) -one of formula ##STR1## by direct cyclization of the compound of the formula ##STR2## with a catalytic amount of phosphonic acid.

Process for the preparation of benzothiazepines by cyclization with

A four step process for transforming (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R)-enantiomers is described. The final compounds are useful intermediates for the synthesis of antibiotics like Chloramphenicol, Thiamphenicol and Florfenicol. The starting products generally are discard products in the synthesis of said antibiotics.

A process for the kinetic resolution of cis or trans enantiomeric mixtures of the compounds of formula ##STR1## wherein R.sub.3 and X have the meanings reported in the specification and the asterisks mark the asymmetric carbon atoms, is described. The compounds of formula III-A are intermediates useful in the preparation of compounds active on the cardiovascular system.

Process for the resolution of 3-(4-substituted-phenyl)-glycidic acid

A crystallization process of crude 5-(2',4'-difluorophenyl)-salicylic acid from a mixture of an aromatic hydrocarbon and an aliphatic ketone for preparing 5-(2',4'-difluorophenyl)-salicylic acid in form II substantially pure is described.

Process for the preparation of 5-(2',4'difluorophenyl)-salicylic acid in

A process is described for the preparation of mono (2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate with improved characteristics of stability, of processing for the preparation of pharmaceutical forms and of stability of the pharmaceutical forms that contain it.

Mono

A process for preparing 2,6-di-t-butyl-4-mercapto-phenol. This is accomplished by sulfonation of the phenol with a silylated sulfonating agent (e.g., trimethylsilyl-chlorosulfonate). The sulfonic acid is then reduced directly or is converted to the sulfonyl halide intermediate which is then reduced to yield the 2,6-di-t-butyl-4-mercapto-phenol.

Process for preparing an intermediate useful in the syntheis of probucol

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Monza, Italy

Claudio Giordano