Pernod Ricard

Zambon Group S.p.a.

Sclavo Spa

Robertet Sa

Solmag S.p.a.

Finpael S.p.a.

Olon S.p.a.

De.bi Derivati Biologici International S.p.a.

Claudio Fuganti

Samuele Frigoli

Stefano Serra

Massimo Barbeni

Rosanna Cardillo

Maurizio Zenoni

Daniel Joulain

Stefano Servi

Angelo Gentile

Gianna Allegrone

Luca Ghirotto

Paolo Cabella

Paolo Casati

Claudio Giordano

Marco Alpegiani

Daniela Faiardi

Davide Longoni

Eva Baldaro

Francesco Squarcia

Biagio Elefante

Pier A Guarda

Ameriga Lazzarini

Claudi O Giordano

Paolo Tubertini

Giuseppe Sacerdote

Angelo Bedeschi

Francesco Pizzocaro

Roberta Pizzocaro

Andrea Vecchione

Aldo Banfi

Gianluca Belogi

Disclosed is a process for the preparation of Enzalutamide comprising the reaction (Scheme 2), wherein R can be alkyl, aryl, aryl-alkyl or heterocyclyl. 

Process for the preparation of enzalutamide

The invention concerns a 3-alkylated crystallized (1R,4S)-p-menthan-(3)-ol derivative, of formula A or B, wherein: either when R&#x3c;2&#x3e; represents hydrogen or a methyl radical, R&#x3c;1&#x3e; represents a &#x2014;(CH2)n-OH where n can be 1, 2 and 3, or when R&#x3c;2&#x3e; represents a hydroxy radical, R&#x3c;1&#x3e; represents a methyl radical or a &#x2014;(CH2)n-OH group where n can be 1, 2 and 3. The invention also concerns methods for preparing same, and perfume, cosmetic or food compositions containing said derivative.

[object Object]

The invention relates to a process for the preparation of duloxetine (1a), comprising the reaction between 1-fluoronaphthalene and 3-N,N-dimethylamino-1-(2-thienyl)-propan-1-ol in the presence of 1,3-dimethyl-2-oxo-hexahydropyrimidine (DMPU) as the solvent; a method for the identification of duloxetine enantiomers and for the determination of its optical purity is also disclosed. 

Process for the preparation of 1-naphthol mixed ethers and intermediates of crystalline forms of (+) and (&#x2212;)-duloxetine

Tazarotene is prepared by deoxygenation of the corresponding S-oxide, in turn obtained according to two alternative synthetic pathways.

Process for the preparation of Tazarotene

Process for the preparation of intermediates useful for the synthesis for benzothiazepines

Process for preparing butanone derivatives

A method for the acylation of the 7-amino group of the cephalosporanic ring, according to which a 7-ACA amino thiazolyl protected adduct is prepared by acylating said amino group by an aminothiazolyl acetic acid whose amino group has been protected by a phenyl acetyl or a phenoxy acetyl group, the amino group being then deprotected by aqueous hydrolysis in the presence of penicillin G amidase or respectively penicillin V amidase.

Method for the acylation of the 7-amino group of the cephalosporanic ring

A process for the preparation of the compounds of formula ##STR1## (wherein R has the meanings reported in the specification) by enzymatic transesterification of enantiomeric mixtures is described. These compounds are intermediates useful in the synthesis of Diltiazem.

Process for the preparation of intermediates useful for the synthesis of

The production of natural delta-decanolide and/or delta-dodecanolide or mixtures thereof, by means of the biohydrogenation of a substrate containing the corresponding unsaturated lactones, delta-decen-2-olide and delta-dodecen-2-olide, respectively, and mixtures thereof, is performed by means of the use of a microorganism chosen from the group consisting of Saccharomyces delbrueckii, Pichia ohmeri, Hansenula anomala, Pichia stipitis, Debaromyces hansenii, Zymomonas mobilis, Zygosaccharomyces rouxii, Schawnniomyces occidentalis, Sarcina lutea and Geotrichum candidum.

Process for the preparation of saturated delta-decanolide or

Process for the production of gamma- or delta-lactones according to the general formula: ##STR1## in which R is a saturated, mono-, di- or triunsaturated linear alkyl chain comprising from 2 to 10 carbon atoms and in which R.sub.1 is alkylene comprising 2 or 3 carbon atoms, entailing the operation which consists in culturing, in a substrate comprising a hydroxide or hydroperoxide of linoleic acid or of linolenic acid, of their esters or of their glycerides, or of an oleic acid derivative obtained by the photooxygenation of oleic acid or autoxidation of fats which contain it, a microorganism capable of performing beta-oxidations of said substrate.

Process for the microbiological production of gamma- and delta-lactones

The present invention relates to a new method of protection of the carboxy group in the chemistry of the compounds of .beta.-lactam type. According to such a method, the carboxy group is protected by being transformed into its corresponding phenyl-acetoxy-methyl ester, which is then removed by an enzymatic route by means of penicillinacylase. In particular, if the .beta.-lactam compound also bears a phenyl-acetamidic substitutent, this latter is simultaneously hydrolysed during the same step of removal of the carboxy function protecting group.

Method of protection of the carboxy groups in the chemistry of

The process for the microbiological production of gamma (R) decanolide and/or gamma (R) octanolide involves the culture of a micro-organism selected from the group comprising Aspergillus niger, Cladosporium suaveolens, Phanerochaete chrysosporium and Pichia etchellsii in a culture medium that includes a vegetable oil, particularly castor oil, sunflower oil and coconut oil and their hydrolysates.

Process for the microbiological production of gamma (R) decanolide and

A process for preparing L-carnitine (I) wherein

Process for the preparation of L-carnitine

A process for preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester: ##STR1## in which: (a) the compound methyl N(.alpha.-L-aspartyl).alpha.-aminocinnamate, protected at the nitrogen, of formula: ##STR2## where R is a protector group at the nitrogen, is subjected to hydrogenation at the olefin bond by means of gaseous hydrogen in the presence of a hydrogenation catalyst, to give the compound of formula: ##STR3## where R has the aforesaid meaning, in the form of a mixture of .alpha.-L-aspartyl-L-phenylalanine methyl ester protected at the nitrogen, and .alpha.-L-aspartyl-D-phenylalanine methyl ester protected at the nitrogen;

Process for preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester

Growing community of inventors

Milan, Italy

Claudio Fuganti