Alma Mater Studiorum-universitá Di Bologna

Nestec S.a.

Aarhus Universitet

Università Degli Studi Di Roma "la Sapienza"

Université Pierre Et Marie Curie (paris Vi)

Aston University

Cranfield University

Universitat Konstanz

Universitat Innsbruck

Fundacion Centro Nacional De Investigaciones Oncologicas Carlos III

Tampereen Yliopisto

Universität Hohenheim

Université De Namur

Martin-luther-universität Halle-wittenberg

The National Hellenic Research Foundation

Claudio Franceschi

Sebastiano Collino

Beatrice Fraboni

Francesco Zerbetto

Bertrand Friguet

Maria Conte

Isabella Zironi

Daniela Salvatore

Stefania Rapino

Maila Becconi

Stefano Salvioli

Gastone Castellani

Alessandro Marella

Peter Kristensen

Richard Aspinall

Eugenio Mocchegiani

Efstathios S Gonos

Michael Berthold

Paola Caiafa

Nicolle Breusing

Antti Hervonen

Olivier Toussaint

Mercedes Gallardo

Andreas Simm

Jürgen Bernhardt

Beatrix Grubeck-Loebenstein

Daniela Gradinaru

Helen Griffiths

Ewa Sikora

Jan H J Hoeijmakers

Martijn DollÉ

Marco Malavolta

Michael Junk

Alexander BÜRKLE

María Blasco

Tilman Grune

Sofia Moco

The present invention relates to compositions comprising a polymeric matrix or a gel containing functional enzymes capable of re-creating under culture conditions the cell microenvironment existing in vivo. The present invention also relates to devices for cell cultures comprising such compositions, in particular hydrogel and the use thereof to control the chemical microenvironment of a cell culture or mimic physiological or pathological conditions of the in vivo cells. The compositions and the devices described herein could be also used in vitro for evaluating the therapeutic effect of a compound on a determined cell line or on primary cells.

Compositions, devices and methods for the control in vitro of chemical microambient in cell cultures

A torque limiter for transmitting motion from a drive shaft to a driven member, and for selectively disconnecting the driven member from the drive shaft when a predetermined transmitted twisting torque value is exceeded. The torque limiter has a hub fitted to the drive shaft; a rotary first flange fixed to an axial end of the hub; a second flange fixed to the driven member; and a number of modules fitted to the first flange. The first flange is fixed to the hub. The modules are equally spaced along the annular portion of the first flange, and one appendage is located between each two adjacent modules.

Torque limiter

Growing community of inventors

Bologna, Italy

Claudio Franceschi